GW20006A
Anti-Calpastatin antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-BS-17, Anti-Calpain inhibitor, Anti-Calpastatin isoform a, Anti-MGC9402
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About This Item
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-20006A
technique(s)
indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CAST(831)
Application
Anti-Calpastatin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also used for Indirect ELISA.
Biochem/physiol Actions
Calpastatin is an endogenous inhibitor of calpain (Ca2+-dependent cysteine protease). The protein contains an N-terminal domain L and four repetitive calpain-inhibition domains. It plays a role in the proteolysis of amyloid precursor protein. The calpastatin system is involved in membrane fusion processes, such as neural vesicle exocytosis and aggregation of platelet and red-cells.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Instructions
K Croce et al.
The Journal of biological chemistry, 274(51), 36321-36327 (1999-12-14)
Previous studies have indicated that the Ca(2+)-dependent protease, calpain, is activated in platelets within 30-60 s of thrombin stimulation, but specific roles of calpain in platelets remain to be identified. To directly test the functions of calpain during platelet activation
Hu Zhu et al.
Acta pharmacologica Sinica, 23(5), 450-454 (2002-04-30)
To clone a new gene related to human spermatogenesis. cDNA probes of embryo and adult testis were used to hybridize the cDNA microarray of adult testis, and the clones of differential hybridization were sequenced and analyzed. A novel isoform of
M Maki et al.
The Journal of biological chemistry, 264(32), 18866-18869 (1989-11-15)
Calpastatin is a widely distributed endogenous inhibitor protein specifically acting on calpain (Ca2+-dependent cysteine endopeptidase). The inhibitor consists of four inhibitory domains (Domains 1-4) with mutually homologous sequences. NH2-terminal Domain L is non-homologous, and all domains have 120-140 residues each.