GW20030F
Anti-β-2-Microglobulin antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-B2MG
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-20030F
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... B2M(567)
Application
Anti-β-2-Microglobulin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Biochem/physiol Actions
β-2-Microglobulin is a serum protein that forms a non-covalent association with the heavy chain of the major histocompatibility complex (MHC) class I, which is involved in the presentation of peptide antigens to the immune system. Defects in this gene can cause hypercatabolic hypoproteinemia. Amyloidosis is caused upon polymerization of intact β 2-microglobulin in patients on chronic hemodialysis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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P D Gorevic et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(20), 7908-7912 (1986-10-01)
Systemic amyloidosis with a predilection for bone and synovium may complicate the course of patients on long-term hemodialysis. This form of amyloidosis can be typed as distinct from other amyloid diseases by using small tissue samples obtained by bone biopsy
C Bernabeu et al.
Nature, 308(5960), 642-645 (1984-04-12)
Beta 2-microglobulin (beta 2-m) is a highly conserved polypeptide (12,000 molecular weight; 12K) noncovalently associated with the heavy chain (45-48K) of the major histocompatibility complex (MHC) class I antigens. Its synthesis is required for expression of the HLA-A/B and H-2K/D
Manzoor A Wani et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(13), 5084-5089 (2006-03-22)
Two siblings, products of a consanguineous marriage, were markedly deficient in both albumin and IgG because of rapid degradation of these proteins, suggesting a lack of the neonatal Fc receptor, FcRn. FcRn is a heterodimeric receptor composed of a nonclassical
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