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GW21015

Anti-HRAS antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GTPase HRas, Anti-K-ras, Anti-N-ras, Anti-Transforming protein p21, Anti-V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1, Anti-c-H-ras, Anti-p21ras

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00239649
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3

Key Documents

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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat

manufacturer/tradename

Genway 15-288-21015

technique(s)

western blot: suitable

NCBI accession no.

NP_005334.1

UniProt accession no.

P01112

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HRAS(3265)

Immunogen

Immunogen Sequence: GI # 4885425, sequence 116-189
Recombinant V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1

Application

Anti-HRAS antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

GTPase HRas is an enzyme encoded by the HRAS gene in humans. It is located on the short (p) arm of chromosome 11 at position 15.5. Somatic mutation of this gene is restricted to a specific proportion of sporadic pheochromocytoma (PCC). It is strictly monomeric at comparable densities in solution and dimerization is a general property of native H-Ras on membrane surfaces. Missense mutation in the HRAS gene causes an autosomal-dominant syndrome, Costello syndrome.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
029K2298

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K Nicole Weaver et al.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 17(6), 421-430 (2014-08-19)
Costello syndrome is a rare, autosomal-dominant syndrome caused by activating missense mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS), most often p.G12S. Several rare mutations have consistently been associated with a more severe phenotype that is often lethal
Lindsey Oudijk et al.
The Journal of clinical endocrinology and metabolism, 99(7), E1376-E1380 (2014-04-02)
Somatic or germline mutations in up to 15 disease-causative genes are detectable in up to 50% of patients with pheochromocytoma (PCC) and paraganglioma (PGL). Very recently, somatic H-RAS mutations were identified by exome sequencing in approximately 7% in sporadic PCCs
Wan-Chen Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(8), 2996-3001 (2014-02-12)
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within the cell membrane, and this may play a regulatory role in its activation. Lipid anchors composed

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