GW21029
Anti-Interleukin-1β antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-1β
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21029
technique(s)
indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1B(3553)
General description
IL1B (interleukin-1β) is a major proinflammatory cytokine, which is secreted by macrophages and monocytes. It is secreted as an inactive enzyme called pro-IL-1β, which is then cleaved by IL-1β converting enzyme or caspase-1, to produce IL-1β. This gene is localized to human chromosome 2q13-21, and is composed of seven exons and six introns. It is a member of the IL-1 family, which also includes IL-1α and IL-1RN.
Application
Anti-Interleukin-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Interleukin-1 β (IL-1β), also known as catabolin, is a proinflammatory cytokine found to be involved in development of insulin resistance. It mediates the effect of macrophages on insulin signaling and proinflammatory response in human adipocytes. IL-1β blockage may be beneficial for preventing obesity-associated insulin resistance and inflammation in human adipose tissue. Its variants are implicated in the development of diabetic nephropathy (DN).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Dan Gao et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E289-E304 (2014-06-12)
Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major factors that mediate detrimental effects of macrophages on adipocytes may offer potential
Yu He et al.
International orthopaedics, 38(8), 1671-1676 (2014-06-01)
Osteosarcoma is the most common childhood bone cancer. Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. Whether genetic polymorphisms of IL-1B also influence osteosarcoma risk is unknown. The aim of this study was to investigate the association between IL-1B
P E Auron et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(24), 7907-7911 (1984-12-01)
Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and immune responses. We report here the isolation of human IL-1 cDNA. It encodes a precursor polypeptide of 269 amino acids (30,747 Mr). mRNA isolated by hybridization
Ioannis Stefanidis et al.
DNA and cell biology, 33(7), 463-468 (2014-05-21)
Variants of the interleukin-1β gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B C-511T variant and the risk of DN in a Caucasian population.
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