GW21029
Anti-Interleukin-1β antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-1β
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21029
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1B(3553)
General description
IL1B (interleukin-1β) is a major proinflammatory cytokine, which is secreted by macrophages and monocytes. It is secreted as an inactive enzyme called pro-IL-1β, which is then cleaved by IL-1β converting enzyme or caspase-1, to produce IL-1β. This gene is localized to human chromosome 2q13-21, and is composed of seven exons and six introns. It is a member of the IL-1 family, which also includes IL-1α and IL-1RN.
Application
Anti-Interleukin-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Interleukin-1 β (IL-1β), also known as catabolin, is a proinflammatory cytokine found to be involved in development of insulin resistance. It mediates the effect of macrophages on insulin signaling and proinflammatory response in human adipocytes. IL-1β blockage may be beneficial for preventing obesity-associated insulin resistance and inflammation in human adipose tissue. Its variants are implicated in the development of diabetic nephropathy (DN).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Xuefeng Wang et al.
PloS one, 9(9), e106919-e106919 (2014-09-16)
The purpose of our study is to investigate the relationship between IL-1β -31C/T (rs1143627) and -511T/C (rs16944) polymorphisms and the preeclampsia (PE), and analyze the Linkage disequilibrium (LD) and haplotype frequency of the two polymorphism loci. Polymorphisms at -31C/T and
Ioannis Stefanidis et al.
DNA and cell biology, 33(7), 463-468 (2014-05-21)
Variants of the interleukin-1β gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B C-511T variant and the risk of DN in a Caucasian population.
Yu He et al.
International orthopaedics, 38(8), 1671-1676 (2014-06-01)
Osteosarcoma is the most common childhood bone cancer. Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. Whether genetic polymorphisms of IL-1B also influence osteosarcoma risk is unknown. The aim of this study was to investigate the association between IL-1B
Dan Gao et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E289-E304 (2014-06-12)
Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major factors that mediate detrimental effects of macrophages on adipocytes may offer potential
P E Auron et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(24), 7907-7911 (1984-12-01)
Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and immune responses. We report here the isolation of human IL-1 cDNA. It encodes a precursor polypeptide of 269 amino acids (30,747 Mr). mRNA isolated by hybridization
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