GW21031
Anti-Interleukin-10 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-10
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
manufacturer/tradename
Genway 15-288-21031
technique(s)
indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL10(3586)
General description
IL10 (Interleukin 10) is a regulatory cytokine of the human immune system. It belongs to the Class 2 α-helical group of cytokines. The active molecule exists in a tight dimer form made of two interpenetrating subunits in a V-shaped structure. Both halves consist of six α-helices, four originating from one subunit and two from the other.
Application
Anti-Interleukin-10 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Interleukin-10 (IL-10) is an anti-inflammatory cytokine encoded by the IL10 gene in humans and is mapped to chromosome 1. It is an important regulatory cytokine whose involvement extends into diverse areas of the human immune system. It is recognized to have potent and broad-spectrum anti-inflammatory activity and is established in various models of infection, inflammation and even in cancer. IL-10 is an immunosuppressive cytokine, which may help in facilitating carcinogenesis by down-regulating interferon-γ production and supporting tumor escape from the immune response.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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David M Mosser et al.
Immunological reviews, 226, 205-218 (2009-01-24)
Interleukin-10 (IL-10) has long been recognized to have potent and broad-spectrum anti-inflammatory activity, which has been unequivocally established in various models of infection, inflammation, and even in cancer. However, because of the marginal successes of the initial clinical trials using
Sidney Pestka et al.
Annual review of immunology, 22, 929-979 (2004-03-23)
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with
Chia-Wen Tsai et al.
Anticancer research, 34(7), 3731-3737 (2014-07-02)
Interleukin-10 (IL10) is an immunosuppressive cytokine which may facilitate carcinogenesis by down-regulating interferon-gamma production and supporting tumor escape from the immune response. Polymorphisms within the promoter of IL10 gene may not only contribute to differential IL10 expression levels among individuals
J Eskdale et al.
Immunogenetics, 46(2), 120-128 (1997-01-01)
Interleukin-10 (IL-10) is an important regulatory cytokine whose involvement extends into diverse areas of the human immune system. Recent characterization of the promoter and 5' flanking regions has demonstrated the presence of positive and negative regulatory segments in the promoter.
A Zdanov et al.
Structure (London, England : 1993), 3(6), 591-601 (1995-06-15)
Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding, but the nature of the dimer
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