GW21038
Anti-GRO1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CXCL1, Anti-GROα, Anti-Growth-regulated protein α
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-21038
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CXCL1(2919)
Immunogen
Immunogen Sequence: GI # 4504153, sequence 35-107
Recombinant chemokine (C-X-C motif) ligand 1
Application
Anti-GRO1 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
The chemokine (C-X-C motif) ligand 1 (CXCL1) is a protein encoded by the CXCL1 gene in humans and belongs to CXC chemokine family (earlier called as called GRO1 oncogene). It is a cytokine with inflammatory and growth-regulatory properties for melanoma growth-stimulatory activity. CXCL1 is a ligand for CXC chemokine receptor 2 that is expressed on hepatic stellate cells (HSC). It contributes to HSC activation and fibrogenesis. CXCL1 may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. It may be assoiated with bladder carcinogenesis and progression. CXCL1 expression in epithelial cells and its secretion induces angiogenesis. It serves as a target for the embryo′s secretion product IL-1β in decidualised endometrial stromal cells during the peri-implantation period.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Dunja Maria Baston-Büst et al.
Cytokine, 64(1), 79-85 (2013-08-21)
Early molecular interaction between embryo and mother, involving chemoattractants, especially chemokine CXC-motif ligand 1 (CXCL1)(2), determines the pregnancy outcome. So far nothing is known about the signalling cascades of CXCL1 expression in human decidua. The aim of the study was
Makito Miyake et al.
BMC cancer, 13, 322-322 (2013-07-03)
Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, colon and skin cancers, but limited studies to date have described CXCL1 protein expression
Hans Dieter Nischalke et al.
PloS one, 8(11), e80848-e80848 (2013-11-22)
CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on
S Haskill et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(19), 7732-7736 (1990-10-01)
The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity. We have identified two additional genes, GRO beta and GRO gamma, that share 90% and 86%
Makito Miyake et al.
Laboratory investigation; a journal of technical methods and pathology, 93(7), 768-778 (2013-06-05)
Endothelial cell growth and proliferation are critical for angiogenesis; thus, greater insight into the regulation of pathological angiogenesis is greatly needed. Previous studies have reported on chemokine (C-X-C motif) ligand 1 (CXCL1) expression in epithelial cells and that secretion of
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