GW21052
Anti-CKLF antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Chemokine-like factor, isoform b
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21052
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CKLF(51192)
Immunogen
Immunogen Sequence: GI # 7705933, sequence 27-67
Recombinant chemokine-like factor isoform c
Application
Anti-CKLF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Chemokine-like factor is a protein encoded by the CKLF gene in humans. It is the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family and its expression is differentially regulated in myoblasts and myotubes. CKLF has a major role in the recruitment and activation of leucocytes that plays an important role in the pathogenesis of allergic diseases. It can induce proliferation and inhibit apoptosis of human vascular smooth muscle cell by down-regulating Bax and Caspase-3 and by the up-regulation of Bcl-2 expression. CKLF1 may play an important role in inflammation and regeneration of skeletal muscle. It may also play an important role in the development of atopic dermatitis, in the process of immune and inflammatory responses of atherogenesis. CKLF1 is a useful marker for regenerating muscle fibers in inflammatory myopathies.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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W Han et al.
The Biochemical journal, 357(Pt 1), 127-135 (2001-06-21)
Cytokines are small proteins that have an essential role in the immune and inflammatory responses. The repertoire of cytokines is becoming diverse and expanding. Here we report the identification and characterization of a novel cytokine designated as chemokine-like factor 1
Tao Zhang et al.
Zhonghua yi xue za zhi, 92(29), 2069-2074 (2012-12-21)
To explore the effects of chemokine-like factor 1 (CKLF1) on the growth and apoptosis of human vascular smooth muscle cell and understand its mechanism for the induction of cell apoptosis. After the transfection of human vascular smooth muscle cell with
Gao-Yun Yang et al.
International journal of biological sciences, 9(8), 759-765 (2013-08-29)
Human chemokine-like factor 1 (CKLF1), a recently discovered chemokine, has a broad spectrum of biological functions in immune-mediated diseases. It is highly expressed on Th2 lymphocytes and is a functional ligand for human CCR4. CKLF1 has a major role in
Yang Jiao et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 47(21), 1654-1657 (2010-02-09)
To evaluate the difference of the expression level of chemokine-like factor 1 (CKLF1) mRNA and protein between human atherosclerotic plaques and normal arteries. Real-time quantitative PCR was performed with experimental group (24 cases of atherosclerotic plaques) specimens and control group
Luning Shao et al.
Cellular immunology, 263(2), 188-195 (2010-04-16)
Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the
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