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Merck
CN

GW21065

Anti-LTBR antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Lymphotoxin β receptor, Anti-TNFRSF3, Anti-Tumor necrosis factor receptor superfamily member 3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02096841
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21065

technique(s)

western blot: suitable

NCBI accession no.

NP_002333.1

UniProt accession no.

P36941

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LTBR(4055)

General description

LTBR (lymphotoxin β receptor) is a member of the tumor necrosis factor (TNF) superfamily, which also includes LTα and LTβ. It is expressed on stromal, parenchymal and myeloid cells. It is a part of the noncanonical/canonical nuclear factor-κB (NF-κB) signaling pathway.

Immunogen

Immunogen Sequence: GI # 4505039, sequence 106-159
Recombinant lymphotoxin β receptor

Application

Anti-LTBR antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Lymphotoxin β receptor signaling serves pleiotropic functions including the control of lymphoid organ development and support of efficient immune responses against pathogens. LTBR signaling induces chemokine, cytokine or adhesion molecule expression, cell proliferation and cell survival. LTBR is important for development and organization of the secondary lymphoid tissues and its polymorphisms may be associated with risk of IgA nephropathy (IgAN).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
039K1945
029K2264
029K2259

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M J Wolf et al.
Oncogene, 29(36), 5006-5018 (2010-07-07)
The cytokines lymphotoxin (LT) alpha, beta and their receptor (LTbetaR) belong to the tumor necrosis factor (TNF) superfamily, whose founder-TNFalpha-was initially discovered due to its tumor necrotizing activity. LTbetaR signaling serves pleiotropic functions including the control of lymphoid organ development
Su Kang Kim et al.
Immunological investigations, 41(5), 447-457 (2012-03-16)
Lymphotoxin beta receptor (LTBR) is essential for development and organization of the secondary lymphoid tissues. To investigate whether LTBR polymorphisms are associated with IgA nephropathy (IgAN) in Korean children, One hundred ninety nine patients with IgAN and 289 controls were

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