GW21074
Anti-Platelet Basic Protein antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CXCL7, Anti-SCYB7, Anti-Small inducible cytokine B7
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21074
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PPBP(5473)
General description
PPBP (pro-platelet basic protein), also called CXCL7 (chemokine (C-X-C motif) ligand 7), is synthesized as a pro-peptide, which has a molecular weight of 14kDa. It undergoes proteolytic cleavage to produce multiple forms with different biological activities. The longest form produced post cleavage is called PPBP or LDGF (leukocyte-derived growth factor), and is a mitogen for fibroblast cells.
Application
Anti-Platelet Basic Protein antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
PPBP (pro-platelet basic protein), also called chemokine (C-X-C motif) ligand 7 (CXCL7), plays a role in immune response of human phagocytes against the intracellular bacteria. It is found at a significantly higher level in patients with rheumatoid arthritis, which is a chronic inflammatory disease. CXCL7 may act as a helper marker in the follow-up and treatment of developing cardiovascular risk.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Instructions
Cumali Karatoprak et al.
Rheumatology international, 33(5), 1229-1232 (2012-10-12)
The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature
Manoj M Pillai et al.
Blood, 107(9), 3520-3526 (2006-01-05)
The marrow microenvironment consists of several different interacting cell types, including hematopoietic-derived monocyte/macrophages and nonhematopoietic-derived stromal cells. Gene-expression profiles of stromal cells and monocytes cultured together differ from those of each population alone. Here, we report that CXCL7 gene expression
Carolina González-Cortés et al.
Immunobiology, 217(4), 394-401 (2011-11-22)
We have investigated the role of CXCL7 in the immune response of human phagocytes against the intracellular bacteria Mycobacterium tuberculosis and Legionella pneumophila. We have observed that polymorphonuclear neutrophil (PMN) chemotaxis induced by the supernatants of infected monocyte derived macrophages
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW21074-50UG | 04061835783663 |