GW21114
Anti-KIT antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-C-Kit, Anti-CD117, Anti-Mast/stem cell growth factor receptor
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21114
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KIT(3815)
General description
KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) is a tyrosine kinase receptor, the gene of which is localized to human chromosome 4q12. It is a transmembrane receptor, and is also called CD117. It is expressed by mast cells, hematopoietic progenitor cells, germ cells, melanocytes and interstitial cells of Cajal.
Immunogen
Immunogen Sequence: GI # 4557695, sequence 113-208
Recombinant V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Application
Anti-KIT antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Mutations in receptor tyrosine kinase KIT, plays an important role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. KIT tyrosine kinase receptors are implicated in the control of cell growth and differentiation, stem through duplications. KIT and its ligand and the stem cell factor play a key role in normal hematopoiesis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Alessandra Iurlo et al.
Oncotarget, 5(13), 4665-4670 (2014-07-13)
Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity
C Andre et al.
Genomics, 39(2), 216-226 (1997-01-15)
The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and
Abbas Ahmadi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 6763-6768 (2014-04-12)
C-kit receptor (CD117) and its ligand, stem cell factor, play a key role in normal hematopoiesis. It has been demonstrated that its expression extremely increases in leukemias with myeloid commitment. We analyzed findings on CD117 expression together with other myeloid
Yanli Jin et al.
Cancer letters, 353(1), 115-123 (2014-08-05)
Gain-of-function mutations of receptor tyrosine kinase KIT play a critical role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. D816V KIT mutation, found in ∼80% of SM, is resistant to the currently available tyrosine kinase inhibitors (TKIs)
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