GW21168
Anti-RIPK1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-RIP, Anti-Receptor-interacting serine/threonine-protein kinase 1
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21168
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RIPK1(8737)
Immunogen
Immunogen Sequence: GI # 4506539, sequence 337-525
Recombinant receptor (TNFRSF)-interacting serine-threonine kinase 1
Application
Anti-RIPK1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme encoded by RIPK1 gene in humans. It is a multifunctional protein containing an N-terminal Ser/Thr kinase and a C-terminal death domain. RIPK1 acts as a key regulatory molecule involved in regulating both cell death and cell survival. It plays an important role in regulating multiple cellular mechanisms, its dynamic regulation, the physiological and pathological roles of RIP1 kinase in human health and disease. RIP1 is an essential upstream signaling molecule in tumor-necrosis-factor-α-induced necroptosis. It is a novel form of apoptosis-inducing protein and participates in the TNF signaling cascades leading to apoptosis and NF-κB activation.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Dana E Christofferson et al.
Annual review of physiology, 76, 129-150 (2013-10-02)
RIP1 kinase, a multifunctional protein that contains an N-terminal Ser/Thr kinase and a C-terminal death domain, has emerged as a key regulatory molecule involved in regulating both cell death and cell survival. When the proinflammatory cytokine TNFα stimulates its receptor
H Hsu et al.
Immunity, 4(4), 387-396 (1996-04-01)
The death domain of tumor necrosis factor (TNF) receptor-1 (TNFR1) triggers distinct signaling pathways leading to apoptosis and NF-kappa B activation through its interaction with the death domain protein TRADD. Here, we show that TRADD interacts strongly with RIP, another
Tian Xie et al.
Structure (London, England : 1993), 21(3), 493-499 (2013-03-12)
Necroptosis is a cellular mechanism that mediates necrotic cell death. The receptor-interacting serine/threonine protein kinase 1 (RIP1) is an essential upstream signaling molecule in tumor-necrosis-factor-α-induced necroptosis. Necrostatins, a series of small-molecule inhibitors, suppress necroptosis by specifically inhibiting RIP1 kinase activity.
B Z Stanger et al.
Cell, 81(4), 513-523 (1995-05-19)
Ligation of the extracellular domain of the cell surface receptor Fas/APO-1 (CD95) elicits a characteristic programmed death response in susceptible cells. Using a genetic selection based on protein-protein interaction in yeast, we have identified two gene products that associate with
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW21168-50UG | 04061837817908 |
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