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Merck
CN

GW21180

Sigma-Aldrich

Anti-VEGF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-VEGFA, Anti-Vascular endothelial growth factor

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About This Item

MDL number:
UNSPSC Code:
12352203
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... VEGFA(7422)

Immunogen

Immunogen Sequence: GI # 19923240, sequence 40-104
Recombinant vascular endothelial growth factor

Application

Anti-VEGF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Vascular endothelial growth factor A (VEGF-A) is a protein encoded by the VEGFA gene in humans and is mapped to human chromosome 6p12-p21. It is a pluripotent cytokine and angiogenic growth factor that plays an important role in embryonic development and tumor progression. VEGF is secreted from endothelial cells and pericytes in response to hypoxia. It induces angiogenesis and microvascular hyperpermeability. The plasma VEGF levels are significantly associated with vasculitic neuropathy. VEGF is increased by brain-derived neurotrophic factor (BDNF) and enhances angiogenesis through a signal transduction pathway.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Yue Wu et al.
Biochimica et biophysica acta, 1840(9), 2970-2977 (2014-06-17)
Angiogenesis is thought to be important in tumorigenesis and tumor progress. Vascular endothelial growth factor (VEGF) is a pluripotent cytokine and angiogenic growth factor that plays crucial roles in embryonic development and tumor progression. In many types of cancer, VEGF
Woohyok Chang et al.
American journal of ophthalmology, 157(6), 1250-1257 (2014-02-18)
To evaluate the outcome of pars plana vitrectomy, subretinal tissue plasminogen activator (t-PA) infusion and intraocular gas tamponade with and without postsurgical antivascular endothelial growth factor (VEGF) injection for thick submacular hemorrhage due to exudative age-related macular degeneration (AMD). Retrospective
Victor Manolov et al.
Clinical laboratory, 60(9), 1573-1577 (2014-10-09)
Vascular endothelial growth factor (VEGF) is secreted from endothelial cells and pericytes in response to hypoxia. It induces angiogenesis and microvascular hyperpermeability. We observe serum VEGF concentrations in some patients with vasculitic neuropathy. Plasma VEGF was measured using GenWay's human
Atul Kolate et al.
Journal of controlled release : official journal of the Controlled Release Society, 192, 67-81 (2014-07-06)
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in therapeutic delivery and is being used as an add-on tool to the traditional drug delivery methods. Chemically, PEGylation is a term used to denote modification of therapeutic
Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively.
M G Mattei et al.
Genomics, 32(1), 168-169 (1996-02-15)

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