GW21180
Anti-VEGF antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-VEGFA, Anti-Vascular endothelial growth factor
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VEGFA(7422)
Immunogen
Immunogen Sequence: GI # 19923240, sequence 40-104
Recombinant vascular endothelial growth factor
Application
Anti-VEGF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Vascular endothelial growth factor A (VEGF-A) is a protein encoded by the VEGFA gene in humans and is mapped to human chromosome 6p12-p21. It is a pluripotent cytokine and angiogenic growth factor that plays an important role in embryonic development and tumor progression. VEGF is secreted from endothelial cells and pericytes in response to hypoxia. It induces angiogenesis and microvascular hyperpermeability. The plasma VEGF levels are significantly associated with vasculitic neuropathy. VEGF is increased by brain-derived neurotrophic factor (BDNF) and enhances angiogenesis through a signal transduction pathway.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Yue Wu et al.
Biochimica et biophysica acta, 1840(9), 2970-2977 (2014-06-17)
Angiogenesis is thought to be important in tumorigenesis and tumor progress. Vascular endothelial growth factor (VEGF) is a pluripotent cytokine and angiogenic growth factor that plays crucial roles in embryonic development and tumor progression. In many types of cancer, VEGF
Woohyok Chang et al.
American journal of ophthalmology, 157(6), 1250-1257 (2014-02-18)
To evaluate the outcome of pars plana vitrectomy, subretinal tissue plasminogen activator (t-PA) infusion and intraocular gas tamponade with and without postsurgical antivascular endothelial growth factor (VEGF) injection for thick submacular hemorrhage due to exudative age-related macular degeneration (AMD). Retrospective
Victor Manolov et al.
Clinical laboratory, 60(9), 1573-1577 (2014-10-09)
Vascular endothelial growth factor (VEGF) is secreted from endothelial cells and pericytes in response to hypoxia. It induces angiogenesis and microvascular hyperpermeability. We observe serum VEGF concentrations in some patients with vasculitic neuropathy. Plasma VEGF was measured using GenWay's human
Atul Kolate et al.
Journal of controlled release : official journal of the Controlled Release Society, 192, 67-81 (2014-07-06)
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in therapeutic delivery and is being used as an add-on tool to the traditional drug delivery methods. Chemically, PEGylation is a term used to denote modification of therapeutic
Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively.
M G Mattei et al.
Genomics, 32(1), 168-169 (1996-02-15)
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