GW21183
Anti-BRCA1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Breast and ovarian cancer susceptibility protein splice variant
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21183
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BRCA1(672)
Immunogen
Immunogen Sequence: GI # 6552299, sequence 1395-1454
Recombinant breast cancer 1, early onset isoform 1
Application
Anti-BRCA1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
BRCA1 is a human tumor suppressor gene. Its main function is to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest and transcriptional regulation. BRCA1 is associated with breast and ovarian tumor suppression. Mutations in BRCA1 is involved in the pathogenesis of breast and ovarian cancer. BRCA1 promoter methylation is associated with better response to platinum-taxane-based therapy in epithelial ovarian cancer (EOC). BRCA1 mutation may drive the formation of tumors in estrogen-regulated tissues.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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I Ruscito et al.
European journal of cancer (Oxford, England : 1990), 50(12), 2090-2098 (2014-06-04)
Mutations in BRCA1/2 genes are involved in the pathogenesis of breast and ovarian cancer. Inactivation of these genes can also be mediated by hypermethylation of CpGs in the promoter regions. Aim of this study was to analyse the clinical impact
Kienan I Savage et al.
Cancer research, 74(10), 2773-2784 (2014-03-19)
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A major question has been why BRCA1 loss
Sarah J Hill et al.
Genes & development, 28(17), 1957-1975 (2014-09-04)
BRCA1 is a breast and ovarian tumor suppressor. Given its numerous incompletely understood functions and the possibility that more exist, we performed complementary systematic screens in search of new BRCA1 protein-interacting partners. New BRCA1 functions and/or a better understanding of
T Ignatov et al.
Journal of cancer research and clinical oncology, 140(9), 1457-1463 (2014-05-16)
The aim of the current study was to investigate the role of BRCA1 promoter methylation as predictive factor of response to platinum-taxane-based therapy in sporadic ovarian cancer. BRCA1 promoter methylation was analyzed in 42 sporadic epithelial ovarian cancers. The results
Kienan I Savage et al.
Molecular cell, 54(3), 445-459 (2014-04-22)
Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the
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