GW21244
Anti-SRP54 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Signal recognition particle 54 kDa
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
manufacturer/tradename
Genway 15-288-21244
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SRP54(6729)
General description
SRP54 (signal recognition particle 54kDa) is a component of the cytoplasmic ribonucleoprotein complex called SRP. It functionally contains an N-terminal, a central G-domain and an M-domain rich in methionine. It has the SRP19 binding region in its 6 and 8 helices.
Immunogen
Immunogen Sequence: GI # 4507215, sequence 300-504
Recombinant signal recognition particle 54kDa
Application
Anti-SRP54 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Protein SRP54 serves to recognize, bind and transport proteins for the membrane or secretion. The methionine-rich M-domain of protein SRP54 (SRP54M) binds to SRP RNA and the signal peptide as protein emerges from the ribosome. It interacts with nascent signal peptide and SRP RNA. SRP54 helps in regulating the targeted secretory and membrane proteins to the endoplasmic reticulum (ER).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Related Content
Instructions
J Yin et al.
RNA (New York, N.Y.), 7(10), 1389-1396 (2001-10-30)
Assembly of the human signal recognition particle (SRP) entails the incorporation of protein SRP54, mediated by a protein SRP1 9-induced conformational change in SRP RNA. To localize the region that controls this crucial step in the assembly of human SRP
G Bacher et al.
Nature, 381(6579), 248-251 (1996-05-16)
The signal-recognition particle (SRP) is important for the targeting of many secretory and membrane proteins to the endoplasmic reticulum (ER). Targeting is regulated by three GTPases, the 54K subunit of SRP (SRP54), and the alpha- and beta-subunits of the SRP
K Gowda et al.
Gene, 207(2), 197-207 (1998-03-25)
Signal recognition particle (SRP) plays a critical role in the targeting of secretory proteins to cellular membranes. An essential component of SRP is the protein SRP54, which interacts not only with the nascent signal peptide, but also with the SRP
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW21244-50UG | 04061835783731 |