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Merck
CN

GW21256

Sigma-Aldrich

Anti-PSAT1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Phosphoserine aminotransferase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_478059.1

UniProt accession no.

Q5T7G5

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PSAT1(29968)

Immunogen

Immunogen Sequence: GI # 17402893, sequence 290-340
Recombinant phosphoserine aminotransferase isoform 1

Application

Anti-PSAT1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Phosphohydroxythreonine aminotransferase (PSAT) is an enzyme encoded by the PSAT1 gene in humans. It may be implicated in altered serine metabolism and schizophrenia spectrum conditions. PSAT plays a role in the L-serine biosynthesis that could be implicated in colon cancer progression and chemoresistance. It can act as a new interesting target for colorectal cancer (CRC) therapy. Human PSAT gene is regulated depending on tissue specificity and cellular proliferation status with a maximum level expression in the S-phase.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
049K0461
039K0526

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Yuji Ozeki et al.
Neuroscience research, 69(2), 154-160 (2010-10-20)
l-Serine is required for the synthesis of glycine and d-serine, both of which are NMDA receptor co-agonists. Although roles for d-serine and glycine have been suggested in schizophrenia, little is known about the role of the l-serine synthesizing cascade in
Joo Youn Baek et al.
The Biochemical journal, 373(Pt 1), 191-200 (2003-03-14)
In the present study, we first report two forms of human phosphoserine aminotransferase (PSAT) cDNA (HsPSAT alpha and HsPSAT beta). HsPSAT alpha has a predicted open reading frame comprising 324 amino acids, encoding a 35.2 kDa protein (PSAT alpha), whereas
Nadia Vié et al.
Molecular cancer, 7, 14-14 (2008-01-29)
Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development. We first observed that PSAT1

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