GW21285B
Anti-AXO antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Axotrophin variant
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About This Item
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21285B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MARCH7(64844)
Application
Anti-AXO antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
E3 ubiquitin-protein ligase MARCH7 (axotrophin) is an enzyme encoded by the MARCH7 gene in humans and belongs to the MARCH family of proteins. It is a novel family of transmembrane ubiquitin ligases that target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail. MARCH-7 was first identified in mouse embryonic stem cells as a neural stem cell gene. It has a distinct expression profile from that of other MARCH family members.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Cristina A Szigyarto et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 58(4), 301-308 (2009-11-11)
Axotrophin/MARCH-7 was first identified in mouse embryonic stem cells as a neural stem cell gene. Using the axotrophin/MARCH-7 null mouse, we discovered profound effects on T lymphocyte responses, including 8-fold hyperproliferation and 5-fold excess release of the stem cell cytokine
Eric Bartee et al.
Journal of virology, 78(3), 1109-1120 (2004-01-15)
Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion proteins that inhibit the surface expression of glycoproteins such as major histocompatibility complex class I (MHC-I), B7.2, ICAM-1, and CD95(Fas). K3 family proteins contain an amino-terminal PHD/LAP or
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW21285B-50UG | 04061835783755 |