GW21286A
Anti-EWSR1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-RNA-binding protein EWS
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-21286A
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EWSR1(2130)
Immunogen
Immunogen Sequence: GI # 4885225, sequence 380-448
Recombinant ewing sarcoma breakpoint region 1 isoform EWS
Application
Anti-EWSR1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
RNA-binding protein EWS is a protein encoded by the EWSR1 gene in humans and is located on human chromosome 22. It is involved in a wide variety of sarcomas as well as some non-mesenchymal tumours. EWSR1 is a ′promiscuous′ gene that can fuse with many different partner genes, resulting in identical tumours. It can partner with the same genes in morphologically and behaviourally different neoplasms. EWSR1 rearrangement is also associated with a variety of salivary gland lesions including classic myoepitheliomas and hyalinizing clear cell carcinomas (HCCCs). It also acts as a novel modulator of cis-acting replication element (CRE) function in hepatitis C virus (HCV) replication.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Cyril Fisher
Histopathology, 64(1), 134-150 (2013-12-11)
Many soft tissue sarcomas have chromosomal translocations with resultant formation of new fusion genes. Among the genes that can be rearranged, the EWSR1 gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas
Todd E Oakland et al.
Journal of virology, 87(12), 6625-6634 (2013-04-05)
The hepatitis C virus (HCV) genome contains numerous RNA elements that are required for its replication. Most of the identified RNA structures are located within the 5' and 3' untranslated regions (UTRs). One prominent RNA structure, termed the cis-acting replication
Akeesha A Shah et al.
The American journal of surgical pathology, 37(4), 571-578 (2013-02-22)
The Ewing sarcoma breakpoint region 1 (EWSR1) is translocated in many sarcomas. Recently, its rearrangement has been described in salivary gland hyalinizing clear cell carcinomas (HCCCs) and in a subset of soft tissue myoepitheliomas. This study examines the presence of
O Delattre et al.
Nature, 359(6391), 162-165 (1992-09-10)
Ewing's sarcoma and related subtypes of primitive neuroectodermal tumours share a recurrent and specific t(11;22) (q24;q12) chromosome translocation, the breakpoints of which have recently been cloned. Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions
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