GW21301
Anti-RGS1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
manufacturer/tradename
Genway 15-288-21301
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... RGS1(5996)
Immunogen
Immunogen Sequence: GI # 4506515, sequence 80-136
Recombinant regulator of G-protein signalling 1
Application
Anti-RGS1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Regulator of G-protein signaling 1 is a protein encoded by the RGS1 gene in humans and is mapped to chromosome band 1q31. This region is known to be implicated in the pathogenesis of haemopoietic malignancies. The gene RGS1 belongs to RGS family and it impairs MAP kinase activation by mammalian G-protein-linked receptors. It encodes a member of the regulator of G protein family and is found to be overexpressed in gene expression-profiling studies of melanoma. RGS1 may act as a novel prognostic marker for melanoma. The gene may be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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John M Hettema et al.
Psychiatric genetics, 23(2), 56-60 (2013-01-18)
Quantitative trait loci identified in animal models provide potential candidate susceptibility loci for human disorders. In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with
K M Druey et al.
Nature, 379(6567), 742-746 (1996-02-22)
A general property of signal transduction pathways is that prolonged stimulation decreases responsiveness, a phenomenon termed desensitization. Yeast cells stimulated with mating pheromone activate a heterotrimeric G-protein-linked, MAP-kinase-dependent signalling pathway that induces G1-phase cell-cycle arrest and morphological differentiation (reviewed in
J S Newton et al.
Biochimica et biophysica acta, 1216(2), 314-316 (1993-11-16)
We have determined the cDNA sequence of a human B cell specific, immediate early gene, designated 1R20, which is inducible in response to several B cell activation signals. The cDNA sequence predicts a 196 amino acid open reading frame comprising