GW21353
Anti-ITGAX antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CD11c, Anti-Integrin α X
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21353
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGAX(3687)
General description
ITGAX (integrin, αX), also called CD11c, belongs to the integrin superfamily of glycoproteins. It is expressed on monocytes, inflammatory macrophages, dendritic cells, and neutrophils.
Application
Anti-ITGAX antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
The expression of Integrin, αX (complement component 3 receptor 4 subunit) (ITGAX) on monocytes helps in establishing a CMML (chronic myelomonocytic leukemia) diagnosis. Polycystic ovary syndrome (PCOS) is associated with an increase in CD11c expression. Its expression is rare in mantle cell lymphoma (MCL) and may aid in differentiation of CD5+ B-cell neoplasms.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Teresa S Kraus et al.
American journal of clinical pathology, 134(2), 271-277 (2010-07-28)
Flow cytometric immunophenotyping (FCI) aids in the differentiation of chronic lymphocytic leukemia (CLL) from mantle cell lymphoma (MCL); however, overlapping phenotypes may occur. CD11c expression has been reported in up to 90% of CLL cases but has rarely been reported
Zhi Hua Huang et al.
The Journal of clinical endocrinology and metabolism, 98(1), E17-E24 (2012-11-03)
Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS. We tested whether polycystic ovary syndrome (PCOS) is associated with increased ATM infiltration, especially
Payal Sojitra et al.
American journal of clinical pathology, 140(5), 686-692 (2013-10-15)
To examine the utility of CD11c expression on monocytes in normal controls and patients with chronic myelomonocytic leukemia (CMML) (n = 23) with flow cytometric immunophenotyping. Twenty-three CMML samples and 10 control bone marrows submitted for lymphoma staging without evidence
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