GW21361
Anti-ITGB7 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Integrin β-7
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21361
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ITGB7(3695)
Application
Anti-ITGB7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Integrin β-7 is an integrin protein encoded by the ITGB7 gene in humans. The β7 subunit protein is associated with two integrin α subunits on lymphocytes. One β7 integrin and α4 β7, mediate lymphocyte adhesion to endothelium and to fibronectin. ITGB7 is expressed on naive B cells and memory B cells that traffic to the gastrointestinal tract. The integrins are a large family of heterodimeric cell-surface glycoproteins and play a key role in the adherence of cells to other cells and to extracellular matrix proteins. ITGB7 is also expected to play a role in adhesive interactions of leukocytes. Ligation of β(7) can inhibit the induction of CD38 expression.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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M J Guilliano et al.
Journal of immunology (Baltimore, Md. : 1950), 166(4), 2179-2185 (2001-02-13)
Analysis of B cells in the human tonsils identified CD38 expression as a hallmark of germinal center (GC) B cells. However, the signals responsible for the in vivo induction of CD38 have not been determined. The primary site for generation
D J Erle et al.
American journal of respiratory cell and molecular biology, 10(3), 237-244 (1994-03-01)
Integrins are heterodimeric cell-surface glycoproteins that mediate cell-cell and cell-matrix adhesion. We previously identified cDNA encoding a novel integrin beta subunit, beta 7, from bronchoalveolar lavage fluid (BALF) leukocytes. The beta 7 subunit protein is now known to associate with
D J Erle et al.
The Journal of biological chemistry, 266(17), 11009-11016 (1991-06-15)
The integrins are a large family of heterodimeric cell-surface glycoproteins that play key roles in the adherence of cells to other cells and to extracellular matrix proteins. We have previously reported the identification of a novel integrin beta subunit partial
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