GW22307A
Anti-ADFP (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-22307A
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ADFP(123)
Immunogen
Immunogen Sequence: GI # 34577059, sequence 71-240
Recombinant adipose differentiation-related protein
Application
Anti-ADFP (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Adipose differentiation-related protein is a protein encoded by the ADFP gene in humans. It plays a novel role in the regulation of macrophage autophagy during lipopolysaccharide (LPS) stimulation. ADFP is the most abundant lipid droplet (LD)-associated protein found in non-adipose tissue and its expression correlates with intracellular lipid accumulation. Its polymorphism may affect its function and influence the development of metabolic and cardiovascular diseases. It has been observed that prolonged endurance-type exercise training increases the expression of ADFP leading to increases in intramuscular triglyceride (IMTG) content in a type I muscle fiber-type specific manner in type 2 diabetes patients.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Rita Rinnankoski-Tuikka et al.
Metabolism: clinical and experimental, 63(8), 1031-1040 (2014-06-29)
The relation between lipid accumulation and influence of exercise on insulin sensitivity is not straightforward. A proper balance between lipid droplet synthesis, lipolysis, and oxidative metabolism would ensure low local intramyocellular fatty acid levels, thereby possibly protecting against lipotoxicity-associated insulin
Joëlle Magné et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(8), 3090-3099 (2013-04-23)
Perilipin 2 (PLIN2) is the most abundant lipid droplet (LD)-associated protein in nonadipose tissue, and its expression correlates with intracellular lipid accumulation. Here we identified a missense polymorphism, Ser251Pro, that has major effect on protein structure and function, along with
Xuyang Feng et al.
Lipids in health and disease, 13, 10-10 (2014-01-11)
Autophagy is an essential process for breaking down macromolecules and aged/damaged cellular organelles to maintain cellular energy balance and cellular nutritional status. The idea that autophagy regulates lipid metabolism is an emerging concept with important implications for atherosclerosis. However, the
C S Shaw et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1158-E1165 (2012-09-06)
The aim of the present study was to investigate changes in intramuscular triglyceride (IMTG) content and perilipin 2 expression in skeletal muscle tissue following 6 mo of endurance-type exercise training in type 2 diabetes patients. Ten obese male type 2
Laura Sanchez-Lazo et al.
Molecular endocrinology (Baltimore, Md.), 28(9), 1502-1521 (2014-07-25)
Oocyte meiotic maturation requires energy from various substrates including glucose, amino acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for meiotic maturation, which is accompanied by differential expression of numerous genes involved in FAs
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