GW22314F
Anti-LSM4 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-22314F
technique(s)
indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LSM4(25804)
Immunogen
Immunogen Sequence: GI # 6912486, sequence 1-139
Recombinant U6 snRNA-associated Sm-like protein 4
Application
Anti-LSM4 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
U6 snRNA-associated Sm-like protein LSm4 is a protein that, in humans, is encoded by the LSM4 gene. Over-expression of LSm4 affects the translocation of ICln (it is a ubiquitous, multifunctional protein with functions in cell volume regulation and RNA processing) to the cell membrane. It inhibits the activation kinetics and current density of IClswell. LSm4 acts in RNA processing and also as a co-factor in cell volume regulation.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Daniel Schraivogel et al.
Nucleic acids research, 43(15), 7447-7461 (2015-07-15)
MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to translational repression and mRNA decay. Ago proteins interact with a member of the GW protein family, referred to as TNRC6A-C in mammals, which coordinate downstream gene-silencing processes. The
Rosaria Gandini et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 22(5-6), 579-590 (2008-12-18)
ICln is a ubiquitous, multifunctional protein with functions in cell volume regulation and RNA processing, and is thus part of an intricate protein network critically involved in the homoeostasis of cells. To better understand this vital protein network in health
Souvik Ghosh et al.
The EMBO journal, 39(18), e103922-e103922 (2020-08-20)
Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein-level modulation. Here, we report that AGO1x, an evolutionarily conserved translational
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