GW22336B
Anti-ARFIP2 (ab2) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-22336B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ARFIP2(23647)
Immunogen
Immunogen Sequence: GI # 6912602, sequence 100-341
Recombinant ADP-ribosylation factor interacting protein 2 (arfaptin 2)
Application
Anti-ARFIP2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Arfaptin-2 is a protein encoded by the ARFIP2 gene in humans. It binds directly to Rac1 and help in Rac1-mediated signaling pathways. Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family. It is ubiquitously expressed and bound to the GTP and may be involved in Golgi function along with ARF1. Arfaptin-2 is associated in regulating huntingtin protein aggregation, possibly by impairing proteasome function.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Instructions
Ernesto E Ambroggio et al.
PloS one, 8(4), e62963-e62963 (2013-05-03)
Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family in their active GTP-bound state. It has been proposed that BAR domains are able to sense membrane curvature and to induce membrane tubulation. We report
H Kanoh et al.
The Journal of biological chemistry, 272(9), 5421-5429 (1997-02-28)
ADP-ribosylation factors (ARFs) have been implicated in vesicle transport in the Golgi complex. Employing yeast two-hybrid screening of an HL60 cDNA library using a constitutively active mutant of ARF3 (ARF3.Q71L), as a probe, we have identified a cDNA encoding a
L Van Aelst et al.
The EMBO journal, 15(15), 3778-3786 (1996-08-01)
The Rac GTP binding proteins are implicated in actin cytoskeleton-membrane interaction in mammalian cells. In fibroblast cells, Rac has been shown to mediate growth factor-induced polymerization of actin to form membrane ruffles and lamellipodia. We report here the isolation of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW22336B-50UG | 04061837818837 |