GW22390A
Anti-MAT2A antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-22390A
technique(s)
indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MAT2A(4144)
Immunogen
Immunogen Sequence: GI # 5174529, sequence 1-192
Recombinant methionine adenosyltransferase II, α
Application
Anti-MAT2A antibody produced in chicken is suitbale for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Methionine adenosyltransferase (MAT) is an enzyme responsible for S-adenosylmethionine (AdoMet) synthesis and is encoded by two genes, MAT1A and MAT2A. MAT1A and MAT2A encode for liver-specific and non-liver-specific MAT respectively. MAT2A expression is associated with lower AdoMet levels and a dedifferentiated phenotype. The gene expression is modulated as an adaptive response of the cell to l-methionine availability through its conversion to AdoMet. MAT2A is involved in the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Maria L Martínez-Chantar et al.
The Journal of biological chemistry, 278(22), 19885-19890 (2003-03-28)
In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. In liver, MAT1A expression is associated with high AdoMet levels and a differentiated phenotype, whereas MAT2A expression is associated with
Z Mao et al.
Biochemical and biophysical research communications, 248(3), 479-484 (1998-08-15)
Methionine adenosyltransferase (MAT) is a critical cellular enzyme which catalyzes the formation of S-adenosylmethionine, the principal methyl donor. In mammals, two different genes, MAT1A and MAT2A, encode for liver-specific and non-liver-specific MAT, respectively. We have cloned and characterized a 1.4-kb
Mihalis I Panayiotidis et al.
Free radical biology & medicine, 40(2), 348-358 (2006-01-18)
S-Adenosylmethionine (SAM, AdoMet) is the most important methyl donor used for synthesis of nucleic acids, phospholipids, creatine, and polyamines and for methylation of many bioactive molecules. The metabolic response of the lung to oxidative stress of hyperoxia requires increased RNA
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