GW22423F
Anti-PAFAH1B2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat
manufacturer/tradename
Genway 15-288-22423F
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PAFAH1B2(5049)
General description
PAFAH1B2 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 2) forms a component of platelet activating factor acetylhydrolase (paf-ah), which is composed of a regulatory subunit called Pafah1b1. The other two subunits are catalytic and non-identical and are called Pafah1b2 and Pafah1b3. This protein has a molecular weight of 30kDa. It is alternatively transcribed into two isoforms, which differ at their C-termini. One isoforms is specific to testis.
Immunogen
Immunogen Sequence: GI # 4505585, sequence 1-229
Recombinant platelet-activating factor acetylhydrolase, isoform Ib, β subunit 30kDa
Application
Anti-PAFAH1B2 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Platelet-activating factor acetylhydrolase IB subunit β (PAFAH1B2) is a component of plasma PAF-AH, which can hydrolyze oxidized phospholipids and may attenuate the spreading of lipid peroxidation. It plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis. It forms a heterodimer with PAFAH1b3, in erythrocytes, and is responsible for rapid hydrolysis of aspirin.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Gang Zhou et al.
The Journal of biological chemistry, 288(17), 11940-11948 (2013-03-20)
Aspirin is rapidly hydrolyzed within erythrocytes by a heterodimer of PAFAH1b2/PAFAH1b3 but also in plasma by an unidentified activity. Hydrolysis in both compartments was variable, with a 12-fold variation in plasma among 2226 Cleveland Clinic GeneBank patients. Platelet inhibition by
Bruce T Scott et al.
Prostaglandins & other lipid mediators, 85(3-4), 69-80 (2007-12-25)
Platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis. Intracellular paf-ah (paf-ah-Ib) is composed of a regulatory subunit, Pafah1b1
Yutaka Hirashima et al.
Neurosurgery, 70(3), 602-609 (2011-08-26)
Free radicals and lipid peroxidation are thought to be related to the vasospasm generation after subarachnoid hemorrhage (SAH). Plasma platelet-activating factor-acetyl hydrolase (PAF-AH) degrades phospholipids with an oxidatively modified fatty acyl chain. To compare plasma PAF-AH activity and free forms
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