GW22527F
Anti-CAPG antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
manufacturer/tradename
Genway 15-288-22527F
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CAPG(822)
General description
CAPG (capping protein, gelsolin-like) is an actin-binding protein, which is expressed ubiquitously. It belongs to the Ca2+- and polyphosphoinositide-regulated villin/gelsolin superfamily, and caps the barbed end of the growing actin microfilament.
Immunogen
Immunogen Sequence: GI # 4502561, sequence 1-348
Recombinant capping protein (actin filament), gelsolin-like
Application
Anti-CAPG antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Macrophage-capping protein (CAPG) plays a critical role in regulating the migration ability of cells. It is a Ca2+-sensitive protein, which reversibly blocks the barbed ends of actin filaments, but does not sever preformed actin filaments. CAPG helps in promoting tumor cell invasion, but not cell proliferation. It is involved in the process of metastasis by promoting the invasiveness of tumor cells. It can act as a biomarker in risk-stratification therapy for gastric cancer and as a therapeutic target in Hepatocellular carcinoma (HCC). CAPG is also identified as a novel candidate biomarker to predict response to gemcitabine treatment and survival in cholangiocarcinoma as well as lung adenocarcinoma.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Hiroshi Ichikawa et al.
Journal of proteome research, 12(8), 3780-3791 (2013-06-21)
To reveal the proteomic background of lymph node metastasis (LNM) in gastric cancer, we performed a proteomic study of tumor and matched nontumor tissues obtained from surgically resected specimens of 22 patients with or without LNM. Using laser microdissection, we
Noriaki Morofuji et al.
Journal of proteomics, 75(5), 1577-1589 (2011-12-14)
Cholangiocarcinoma is one of the deadliest malignancies worldwide. Recent studies reported that treatment with gemcitabine was effective in prolonging survival. However, as the treatment only benefited a limited subset of patients, selection of patients before treatment is required. To discover
Fangchun Shao et al.
The Tohoku journal of experimental medicine, 225(2), 95-101 (2011-09-13)
Gelsolin-like actin-capping protein (CapG), a ubiquitous actin-binding protein, has been shown to play a critical role in regulating the migration ability of cells. In this study, we investigated CapG expression in lung cancer cell lines under hypoxia and evaluated the
Kazuya Kimura et al.
Journal of proteomics, 78, 362-373 (2012-10-23)
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide. We performed a proteomic study to understand the molecular mechanisms underlying metastasis in HCC. Among the 3491 protein spots observed by two-dimensional difference gel electrophoresis (2D-DIGE), we found that
G A Dabiri et al.
The Journal of biological chemistry, 267(23), 16545-16552 (1992-08-15)
Macrophage capping protein (MCP) is a Ca(2+)-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. The human cDNA for MCP has been cloned and sequenced. The derived amino acid sequence predicts
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