GW22754
Anti-Integrin β1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-22754
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ITGB1(3688)
Application
Anti-Integrin β1 antibody produced in chicken was used in western blot analysis of amoeba whole-cell lysates and membrane fractions for the detection of integrin-like proteins. It is also suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Integrin β-1 is a protein encoded by the ITGB1 gene in humans and regulates multiple epithelial cell functions by connecting cells with the extracellular matrix. It helps in enhancing epithelial-to-mesenchymal transition (EMT) through FAK-AKT signaling pathway. The protein expression may have potential in identifying the stage of colorectal liver metastases and may act as a marker of prognosis in these patients.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Nikolaos Vassos et al.
International journal of clinical and experimental pathology, 7(1), 288-300 (2014-01-16)
Integrins are cell surface adhesion molecules (CAM) that regulate via intercellular and cell-matrix signaling various cellular processes including wound healing, cell differentiation, division, growth, migration and metastatic dissemination. Although a correlation between carcinogenesis and changes in integrin expression, especially β1
Nancy Ernst et al.
PloS one, 8(12), e84356-e84356 (2014-01-05)
β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells (ePCs) in situ remains to be
The cytoplasmic extension of the integrin β6 subunit regulates epithelial-to-mesenchymal transition.
Carlin Lee et al.
Anticancer research, 34(2), 659-664 (2014-02-11)
Prognosis for oral cancer patients has not improved in over 60 years due to invasion and recurrence. To understand the invasive behavior of this tumor, we evaluated the role of the αvβ6 integrin. Invasive oral SCC cells express the αvβ6