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Merck
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GW22771

Sigma-Aldrich

Anti-PYY (ab1) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-PYY1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

manufacturer/tradename

Genway 15-288-22771

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PYY(5697)
mouse ... Pyy(217212)

Immunogen

Immunogen Sequence: GI # 21703868, sequence 29-40
Synthetic peptide sequence of YY (Mus musculars).

Application

Anti-PYY (ab1) antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Peptide YY (PYY, also known as peptide tyrosine tyrosine) is a peptide encoded by the PYY gene in humans. It is helpful in mediating the beneficial effects of bariatric surgery and plays a role in glucose homeostasis. PYY is affected in various gastrointestinal diseases and disorders.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Hyun-Jung Cho et al.
Cell and tissue research, 357(1), 63-69 (2014-05-21)
A sub-group of enteroendocrine cells (L cells) release gastrointestinal hormones, GLP-1 and PYY, which have different but overlapping physiological effects, in response to intraluminal nutrients. Whilst their release profiles are not identical, how the plasma levels of these two hormones
Therese E Fazio Coles et al.
Cell and tissue research, 379(1), 109-120 (2019-09-04)
Recent studies reveal substantial species and regional differences in enteroendocrine cell (EEC) populations, including differences in patterns of hormone coexpression, which limit extrapolation between animal models and human. In this study, jejunal samples, with no histologically identifiable pathology, from patients
Josiane Fakhry et al.
Cell and tissue research, 369(2), 245-253 (2017-04-18)
There is general consensus that enteroendocrine cells, EEC, containing the enteric hormone cholecystokinin (CCK) are confined to the small intestine and predominate in the duodenum and jejunum. Contrary to this, EEC that express the gene for CCK have been isolated
Josiane Fakhry et al.
Cell and tissue research, 376(1), 37-49 (2018-11-24)
Gastric endocrine cell hormones contribute to the control of the stomach and to signalling to the brain. In other gut regions, enteroendocrine cells (EECs) exhibit extensive patterns of colocalisation of hormones. In the current study, we characterise EECs in the
Sean Manning et al.
Annual review of physiology, 76, 585-608 (2013-11-06)
Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients

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