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Merck
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GW22788A

Sigma-Aldrich

Anti-TLR3 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD03456040
UNSPSC Code:
12352203

Key Documents

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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

manufacturer/tradename

Genway 15-288-22788A

technique(s)

western blot: suitable

NCBI accession no.

NP_003256.1

UniProt accession no.

O15455

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TLR3(7098)

General description

Toll-like receptor 3 (TLR3) is a protein encoded by the TLR3 gene in humans. It is a member of the Toll-like receptor family localized in various intracellular structures such as endosomes and endoplasmic reticulum.

Immunogen

Immunogen Sequence: GI # 4507531, sequence 401-600
Recombinant toll-like receptor 3

Application

Anti-TLR3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Toll-like receptor 3 (TLR3) is mainly involved in both the innate and adaptive immune systems. TLR3 activation in the skin induces inflammation and increases the expression of genes involved in skin barrier repair while TLR2 activation prevents excessive inflammation by blocking downstream TLR3 signaling.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
039K1743
019K0501
039K2257
039K0449

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Regina Vontell et al.
Journal of neuropathology and experimental neurology, 74(3), 273-285 (2015-02-11)
Toll-like receptor-3 (TLR3) has been identified in a variety of intracellular structures (e.g. endosomes and endoplasmic reticulum); it detects viral molecular patterns and damage-associated molecular patterns. We hypothesized that, after white matter injury (WMI) has occurred, localization and activation of
Andrew W Borkowski et al.
The Journal of investigative dermatology, 134(9), 2315-2320 (2014-05-03)
UV radiation poses a significant risk to human health. The mechanisms that help repair UV-damaged cells have recently been more clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from necrotic keratinocytes following UV damage.
Konstantin S Mineev et al.
FEBS letters, 588(21), 3802-3807 (2014-09-15)
Toll-like receptors (TLRs) take part in both the innate and adaptive immune systems. The role of the transmembrane domain in TLR signaling is still elusive, while its importance for the TLR activation was clearly demonstrated. In the present study the

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