GW22793B
Anti-ITM2B antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
manufacturer/tradename
Genway 15-288-22793B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITM2B(9445)
General description
The previously assigned protein identifier Q5W0A3 has been merged into Q9Y287. Full details can be found on the UniProt database.
Application
Anti-ITM2B antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Integral membrane protein 2B is a protein encoded by the ITM2B gene in humans. It is a type II transmembrane protein that is trasnported through the secretory pathway to the cell surface and is processed by furin and ADAM10 (a disintegrin and metalloproteinase domain 10). The ITM2B protein binds to amyloid precursor protein to halt amyloid-β production and inhibits amyloid-β aggregation. It is linked to Alzheimer′s disease (AD). In early stages of AD, an increased deposition of this protein is found. Mutation in this gene is also associated with dementia or retinal disease.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Related Content
Instructions
Maria Tsachaki et al.
Glycobiology, 21(10), 1382-1388 (2011-07-15)
Two different mutated forms of BRI2 protein are linked with familial British and Danish dementias, which present neuropathological similarities with Alzheimer's disease. BRI2 is a type II transmembrane protein that is trafficked through the secretory pathway to the cell surface
Marta Del Campo et al.
Neurobiology of aging, 35(7), 1596-1604 (2014-02-15)
BRI2 protein binds amyloid precursor protein to halt amyloid-β production and inhibits amyloid-β aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD). Here, we investigate the possible involvement of BRI2 in human AD pathogenesis. BRI2 containing
Isabelle Audo et al.
Human molecular genetics, 23(2), 491-501 (2013-09-13)
Inherited retinal diseases are a group of clinically and genetically heterogeneous disorders for which a significant number of cases remain genetically unresolved. Increasing knowledge on underlying pathogenic mechanisms with precise phenotype-genotype correlation is, however, critical for establishing novel therapeutic interventions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GW22793B-50UG | 04061838064578 |