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Merck
CN

GW22833

Sigma-Aldrich

Anti-α-2-Catenin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

manufacturer/tradename

Genway 15-288-22833

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CTNNA2(1496)

Immunogen

Immunogen Sequence: GI # 7656999, sequence 141-300
Recombinant catenin, α 2

Application

Anti-α-2-Catenin antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

CTNNA2 encodes α-catenin 2 and is mapped to the p11.1-p12 region of human chromosome 2. The gene encodes for a brain-expressed α-catenin that is critical for synaptic contact. It is differentially regulated by smoking in schizophrenic patients. The differences in gene expression in postmortem brain of schizophrenic non-smokers implicates this gene in the disease. It is a tumour suppressor gene frequently mutated in laryngeal carcinomas.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Sharon Mexal et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B(6), 759-768 (2008-01-01)
The alphaN-catenin (CTNNA2) gene represents a promising candidate gene for schizophrenia based upon previous genetic linkage, expression, and mouse knockout studies. CTNNA2 is differentially regulated by smoking in schizophrenic patients. In this report, the genomic structure of a primate-specific alphaN-catenin
J M Claverie et al.
Genomics, 15(1), 13-20 (1993-01-01)
We report the characterization of a human cDNA encompassing the complete coding region of a 945-residue putative protein (CAP-R) 80% identical to the recently described murine 102-kDa alpha-catenin (CAP102). The CAP-R protein mostly differs from CAP102 by the presence of
A Terracciano et al.
Translational psychiatry, 1, e49-e49 (2011-01-01)
The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score
Miriam Fanjul-Fernández et al.
Nature communications, 4, 2531-2531 (2013-10-09)
Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome

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