GW22894
Anti-RGS8 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Regulator of G-protein signaling 8
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
manufacturer/tradename
Genway 15-288-22894
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... RGS8(85397)
Immunogen
Immunogen Sequence: GI # 16117777, sequence 1-85
Recombinant regulator of G-protein signalling 8
Application
Anti-RGS8 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Regulator of G-protein signaling 8 is a protein encoded by the RGS8 gene in humans. It is a neuron-specific regulator of G-protein signaling (RGS) protein that belongs to the B/R4 subfamily. RGS8 is recruited to the plasma membrane where G-proteins are activated mainly by direct association with Gα. It regulates G-protein signaling protein induced in neuronally differentiated P19 cells. RGS proteins help in modulating signaling through heterotrimeric G-proteins. It acts to enhance the intrinsic GTPase activity of the Gα subunit. RGS protein is found to enhance the "kinetic efficacy" of the ternary complex by direct association with the G-protein α subunit. RGS8 expression is improved upon the ′kinetic efficacy′ of G-protein activation.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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A Benians et al.
Biochemical Society transactions, 32(Pt 6), 1045-1047 (2004-10-28)
The RGS (regulators of G-protein signalling) protein family sharpen signalling kinetics through heterotrimeric G-proteins by enhancing the GTPase activity of the G-protein alpha subunit. Paradoxically, they also accelerate receptor-stimulated activation. We investigated this paradox using the cloned G-protein gated K(+)
Amy Benians et al.
The Journal of biological chemistry, 280(14), 13383-13394 (2005-01-29)
Regulators of G-protein signaling (RGS) proteins modulate signaling through heterotrimeric G-proteins. They act to enhance the intrinsic GTPase activity of the Galpha subunit but paradoxically have also been shown to enhance receptor-stimulated activation. To study this paradox, we used a
Osamu Saitoh et al.
Methods in enzymology, 390, 129-148 (2004-10-19)
RGS8 was identified as a regulator of G-protein signaling (RGS) protein induced in neuronally differentiated P19 cells. This article presents methods used to estimate the binding activity and selectivity between RGS8 and Galpha subunits. It describes three kinds of in
Ikuo Masuho et al.
Journal of neurochemistry, 88(1), 161-168 (2003-12-17)
RGS (regulators of G-protein signaling) proteins comprise a large family that modulates heterotrimeric G-protein signaling. This protein family has a common RGS domain and functions as GTPase-activating proteins for the alpha-subunits of heterotrimeric G-proteins located at the plasma membrane. RGS8
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