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Merck
CN

H0411

Sigma-Aldrich

Hepatocyte Growth Factor Receptor (c-Met)/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym(s):

HGF Receptor (c-Met)

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About This Item

MDL number:
UNSPSC Code:
51111800
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biological source

mouse

recombinant

expressed in baculovirus infected Sf21 cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 128 kDa

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Met(17295)

Biochem/physiol Actions

Heterodimeric transmembrane glycoprotein with binding capacity for c-Met. Activation of this receptor has been correlated with induction of the Ras pathway.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to bind human HGF.

Other Notes

Extracellular domain fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Cornoglio, P.M. et al.
Guidebook to Cytokines and Their Receptors, 185-185 (1994)
A M Chan et al.
Oncogene, 2(6), 593-599 (1988-06-01)
The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor. This protein can be divided into

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