Name: 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₂O₃

CAS Number:

54845-95-3

Molecular Weight:

320.47

Beilstein:

2470466

MDL number:

MFCD00063590

UNSPSC Code:

12352200

PubChem Substance ID:

24895431

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Assay

≥97.0% (HPLC)

concentration

~150 μg/mL in ethanol

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O

InChI

1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1

InChI key

JSFATNQSLKRBCI-VAEKSGALSA-N

Biochem/physiol Actions

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

Pictograms

GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H315,H319,H335

Precautionary Statements

P210 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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