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Merck
CN

H116

6-Hydroxydopamine hydrobromide

contains ascorbic acid as stabilizer, ≥98% (HPLC)

Synonym(s):

2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA

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About This Item

Linear Formula:
(HO)3C6H2CH2CH2NH2 · HBr
CAS Number:
636-00-0
Molecular Weight:
250.09
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
24895432
EC Number:
211-247-0
Beilstein/REAXYS Number:
3713280
MDL number:
MFCD00012894

Key Documents

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InChI key

MLACDGUOKDOLGC-UHFFFAOYSA-N

InChI

1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

SMILES string

Br.NCCc1cc(O)c(O)cc1O

assay

≥98% (HPLC)

contains

ascorbic acid as stabilizer

storage temp.

−20°C

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General description

Convenient, stabilized preparation of the dopaminergic neurotoxin, 6-hydroxydopamine.
Solutions should be freshly prepared and protected from exposure to light.

Preparation Note

The addition of 2 mL of buffer per 5 mg vial provides a solution containing 10 mM 6-hydroxydopamine and 0.01% (w/v) ascorbic acid.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000051379
0000039010
066M4602V
083M4624V
031M4605V

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William Menegas et al.
Nature neuroscience, 21(10), 1421-1430 (2018-09-05)
Midbrain dopamine neurons are well known for their role in reward-based reinforcement learning. We found that the activity of dopamine axons in the posterior tail of the striatum (TS) scaled with the novelty and intensity of external stimuli, but did
Woori Kim et al.
Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
Dopamine (DA) neurons in sporadic Parkinson's disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA
Camille Ravel-Godreuil et al.
iScience, 24(7), 102756-102756 (2021-07-20)
Age is a major risk factor for neurodegenerative diseases like Parkinson's disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the neurodegenerative process. Here, we investigated the consequences
Julio C Tobón-Velasco et al.
Toxicology, 304, 109-119 (2013-01-01)
6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to
Ana Freitas et al.
Antioxidants (Basel, Switzerland), 10(7) (2021-08-07)
Parkinson's disease's etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has
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