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Merck
CN

H1254

8-Hydroxyquinoline glucuronide

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C15H15NO7
CAS Number:
Molecular Weight:
321.28
UNSPSC Code:
12352204
PubChem Substance ID:
EC Number:
238-724-6
MDL number:
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assay

≥95%

form

powder

color

light green

SMILES string

O[C@@H]1[C@H](O[C@H]([C@H](O)[C@H]1O)C(O)=O)Oc2cccc3cccnc23

General description

Substrate for the histochemical demonstration of β-glucuronidase and for quantitative assay systems.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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T Unak et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 47(7), 645-647 (1996-07-01)
8-Hydroxy-quinolyl-glucuronide (8-HOQ-Glu) can be deglucuronidated by the beta-glucoronidase enzyme, which has an activity that is considerably high in certain kinds of cancer cell. Owing to this enzyme activity, 8-HOQ-Glu can be considered as a potential anti-cancer drug. The combination of
Andrew D Pris et al.
Analytical chemistry, 81(24), 9948-9954 (2009-11-18)
Enabling trace chemical detection equipment utilized in the field to transduce a biodetection assay would be advantageous from a logistics, training, and maintenance standpoint. Described herein is an assay design that uses an unmodified, commercial off-the-shelf (COTS) ion trap mobility
Peter Tobin et al.
British journal of clinical pharmacology, 62(1), 122-129 (2006-07-18)
Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study was to determine