H135
5-Hydroxydecanoic acid sodium salt
≥97% (HPLC)
Synonym(s):
5-hydroxydecanoate sodium salt
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About This Item
Empirical Formula (Hill Notation):
C10H19NaO3
CAS Number:
Molecular Weight:
210.25
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
SMILES string
[Na+].CCCCCC(O)CCCC([O-])=O
InChI
1S/C10H20O3.Na/c1-2-3-4-6-9(11)7-5-8-10(12)13;/h9,11H,2-8H2,1H3,(H,12,13);/q;+1/p-1
InChI key
YNAGNECWEKMWRM-UHFFFAOYSA-M
Biochem/physiol Actions
Blocks post-ischemic actions of the K+ channel activator cromakalim.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Asger Andersen et al.
Cardiology, 123(3), 177-180 (2012-11-07)
We investigated whether ischemic preconditioning (IPC) protects the right ventricular (RV) myocardium against ischemic injury in hearts treated with the specific mitochondrial ATP-sensitive potassium (K(ATP)) channel blocker 5-hydroxydecanoate (5-HD). Hearts from male Wistar rats (300 g, n = 39) were
Pinkee Phukon et al.
Biotechnology letters, 35(4), 607-611 (2012-12-25)
Using a new isolate of Pseudomonas aeruginosa, we obtained 7 g cell dry wt (CDW/l) using 5 % (w/v) glucose. Crude polyhydroxyalkanoates were obtained at 14.6 % of CDW. FTIR and NMR analysis confirmed that this was a new co-polymer:
Germán A Colareda et al.
The Journal of pharmacy and pharmacology, 70(9), 1174-1187 (2018-06-23)
Low-flow ischemia (LFI) is consequent to coronary disease and produces cardiac stunning during reperfusion (R). Energetic performance and mechanisms of Ca2+ handling during LFI/R are not known. Moreover, cardioprotection of the phytoestrogen genistein (Gen) remains to be demonstrated in LFI/R.
Ischemic preconditioning of the right ventricle: a new application for an old concept?.
Tuvia Ben Gal et al.
Cardiology, 123(3), 175-176 (2012-11-07)
G J Grover et al.
Journal of cardiovascular pharmacology, 16(6), 853-864 (1990-12-01)
The detailed antiischemic pharmacology of the potassium channel activator cromakalim was determined in isolated globally ischemic rat hearts and a canine model of coronary occlusion and reperfusion. Cromakalim significantly improved reperfusion function in rat hearts starting at a concentration of
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