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H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

Name: (<I>R</I>)-(+)-8-Hydroxy-DPAT hydrobromide
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₅NO · HBr

CAS Number:

78095-19-9

Molecular Weight:

328.29

NACRES:

NA.77

PubChem Substance ID:

24278480

UNSPSC Code:

12352200

MDL number:

MFCD00153810

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated, protect from light

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]25/D +68.2°, c = 1 in methanol(lit.)

storage condition

desiccated, protect from light

color

white to off-white

solubility

H₂O: >10 mg/mL at ±60 °C (with sonication)

SMILES string

Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1

InChI

1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1

InChI key

BATPBOZTBNNDLN-PFEQFJNWSA-N

Gene Information

human ... HTR1A(3350)

Description

Application

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:

in mice to test the activity of the serotonin receptor
to test its effect on zebrafish melanocyte migration and survival
to stimulate hippocampal neurons

Biochem/physiol Actions

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT_1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Mice do not habituate to metabolism cage housing-a three week study of male BALB/c mice

Kalliokoski O, et al.

PLoS ONE, 8(3), 1176-1185 (2013)

Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice.

Jan Brosda et al.

ACS chemical neuroscience, 6(7), 1176-1185 (2015-03-18)

Brain serotonin (5-HT) is involved in the control of food intake. The ingestive effects of 5-HT are mediated by various receptor subtypes, among others the 5-HT1A receptor. While the involvement of presynaptic 5-HT1A receptors is regarded as certain, the role

Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits.

Masatoshi Nagano et al.

Scientific reports, 8(1), 13675-13675 (2018-09-14)

Disturbance of neurotransmitters and neuromodulators is thought to underlie the pathophysiology of autism spectrum disorder (ASD). Studies of 15q dup mouse models of ASD with human 15q11-13 duplication have revealed that restoring serotonin (5-HT) levels can partially reverse ASD-related symptoms

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