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H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

≥98% (HPLC), solid

Synonym(s):

(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
78095-19-9
Molecular Weight:
328.29
NACRES:
NA.77
PubChem Substance ID:
24278480
UNSPSC Code:
12352200
MDL number:
MFCD00153810
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]25/D +68.2°, c = 1 in methanol(lit.)

storage condition

desiccated, protect from light

color

white to off-white

solubility

H2O: >10 mg/mL at ±60 °C (with sonication)

SMILES string

Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1

InChI

1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1

InChI key

BATPBOZTBNNDLN-PFEQFJNWSA-N

Gene Information

human ... HTR1A(3350)

Application

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
  • in mice to test the activity of the serotonin receptor
  • to test its effect on zebrafish melanocyte migration and survival
  • to stimulate hippocampal neurons

Biochem/physiol Actions

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
(R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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