H156
(+)-3-Hydroxymorphinan hydrobromide
Synonym(s):
(+)-9α,13α,14α-Morphinan-3-ol
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About This Item
Empirical Formula (Hill Notation):
C16H21NO · HBr
CAS Number:
Molecular Weight:
324.26
PubChem Substance ID:
UNSPSC Code:
12352204
InChI
1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1
InChI key
LJAQABDSIONCIU-KHUAAREISA-N
SMILES string
Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1
Quality Level
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
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Jong Yup Kim et al.
Chemical & pharmaceutical bulletin, 56(7), 985-987 (2008-07-02)
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available
High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up.
H Mascher
Journal of chromatography, 420(1), 217-222 (1987-09-04)
Z R Chen et al.
Therapeutic drug monitoring, 12(1), 97-104 (1990-01-01)
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous determination of dextromethophan, dextrorphan, 3-hydroxymorphinan, and 3-methoxymorphinan in plasma and urine. A conventional solvent-solvent extraction procedure was used for the isolation of the analytes from plasma
K C Carlsson et al.
Acta anaesthesiologica Scandinavica, 48(3), 328-336 (2004-02-26)
Dextromethorphan, a clinically available N-methyl-D-aspartic acid (NMDA) receptor antagonist, has an analgesic effect in patients with diabetic neuropathy. The aim of this study was to evaluate the analgesic and adverse effects of a single high dose of dextromethorphan on spontaneous
N Nagai et al.
Biopharmaceutics & drug disposition, 17(5), 421-433 (1996-07-01)
The plasma concentration and cumulative urinary excretion over 34 h of dextromethorphan, free and conjugated dextrorphan, and 3-hydroxymorphinan were determined in seven healthy Japanese subjects after oral administration of 30 mg dextromethorphan hydrobromide. Conjugated metabolites were extensively present, whereas no
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