H174
(±)-3-Hydroxyphenylglycine
powder
Synonym(s):
(±)-α-Amino-3-hydroxybenzeneacetic acid, (±)-3-HPG
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About This Item
Empirical Formula (Hill Notation):
C8H9NO3
CAS Number:
Molecular Weight:
167.16
UNSPSC Code:
12352200
MDL number:
form
powder
color
white
solubility
DMSO: 4 mg/mL, H2O: 5 mg/mL
SMILES string
NC(C(O)=O)c1cccc(O)c1
Biochem/physiol Actions
Metabotropic glutropic glutamate receptor agonist possessing some selectivity for mGluR1.
Disclaimer
Hygroscopic, photosensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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A Buisson et al.
Neuropharmacology, 34(8), 1081-1087 (1995-08-01)
We examined the effect of two novel phenylglycine derivative drugs on excitotoxicity in murine cortical cell cultures: S-4-carboxy-3-hydroxy-phenylglycine (4C3HPG), a selective agonist of mGluRs 2/3 and an antagonist at mGluRs 1/5, and S-3 hydroxy-phenylglycine (3HPG), an agonist of mGluRs 1/5.
I Brabet et al.
Neuropharmacology, 34(8), 895-903 (1995-08-01)
The effects of the phenylglycine derivatives, alpha-methyl-4-carboxyphenylglycine (MCPG), 4-carboxyphenylglycine (4CPG), 4-carboxy-3-hydroxyphenylglycine (4C3HPG), 3-hydroxyphenylglycine (3HPG) and 3,5-dihydrohyphenylglycine (DHPG) were tested on LLC-PK1 cells transiently expressing the rat mGluR1a or mGluR5a receptors. As previously reported by others, (S)-3HPG and (RS)-DHPG were found
Y Hayashi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(5 Pt 2), 3370-3377 (1994-05-01)
The metabotropic glutamate receptors (mGluRs) consist of at least seven different subtypes and are coupled to intracellular signal transduction via G proteins. However, the lack of specific antagonists for the mGluRs limited the precise characterization of the role of the