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Merck
CN

H1763

Sigma-Aldrich

Hippuryl-Gly-Gly

Synonym(s):

N-Benzoyl-Gly-Gly-Gly

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About This Item

Empirical Formula (Hill Notation):
C13H15N3O5
CAS Number:
Molecular Weight:
293.28
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
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Assay

≥99% (HPLC)

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

OC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1

InChI

1S/C13H15N3O5/c17-10(15-8-12(19)20)6-14-11(18)7-16-13(21)9-4-2-1-3-5-9/h1-5H,6-8H2,(H,14,18)(H,15,17)(H,16,21)(H,19,20)

InChI key

CYQZRSVDAIOAIY-UHFFFAOYSA-N

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General description

Substrate for angiotensin converting enzyme (ACE)

Regulatory Information

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T A Stewart et al.
Peptides, 2(2), 145-152 (1981-01-01)
We purified peptidyl-dipeptidase (converting enzyme, EC 3.4.15.1) to homogeneity from the membrane fraction of human lung and for comparison, from human and hog kidney. The membrane-bound lung enzyme was purified 1800-fold with 19% yield, and the kidney enzyme 640-fold with
Simple radioassay for measuring serum activity of angiotensin-converting enzyme in sarcoidosis.
P K Rohatgi et al.
Chest, 78(1), 69-76 (1980-07-01)
L Mor et al.
Journal of pharmacological methods, 23(2), 141-153 (1990-04-01)
We have developed a pressure-dependent isolated lung perfusion system that can be used for the determination of pulmonary enzyme activity and kinetics under physiologic conditions. This development was done using two different artificial radiolabeled substrates, glycine-1-hippuryl-L-histidyl-L-leucine and phenyl-4(n)-hippuryl-glycyl-glycine, for the
Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme).
H Y Yang et al.
The Journal of pharmacology and experimental therapeutics, 177(1), 291-300 (1971-04-01)
J Marchetti et al.
Kidney international, 31(3), 744-751 (1987-03-01)
Angiotensin I converting enzyme (ACE) and kininase activities were measured in various segments of the rabbit nephron. ACE was determined with tritiated hippuryl-glycylglycine as substrate. Lysyl-bradykinin (LBK) hydrolysis (kininase activity) was measured by radioimmunoassay. ACE was only found in the

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