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H2779

Sigma-Aldrich

HistoChoice® Clearing Agent

greener alternative

alternative to toluene and xylene

Synonym(s):

dewaxing mixture for paraffin tissue sections

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10 G
¥535.20
100 G
¥1,683.90
500 G
¥5,629.26

¥535.20


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10 G
¥535.20
100 G
¥1,683.90
500 G
¥5,629.26

About This Item

UNSPSC Code:
12171500
NACRES:
NA.47

¥535.20


In StockDetails


Request a Bulk Order

Quality Level

form

liquid

greener alternative product characteristics

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

colorless

density

0.760-0.820 g/mL

application(s)

hematology
histology

greener alternative category

storage temp.

room temp

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GF01979477GF17066178GF59041740
manufacturer/tradename

Goodfellow 332-723-33

manufacturer/tradename

Goodfellow 019-794-77

manufacturer/tradename

Goodfellow 170-661-78

manufacturer/tradename

Goodfellow 590-417-40

form

mesh

form

mesh

form

mesh

form

mesh

resistivity

5.0 μΩ-cm, 20°C

resistivity

5.0 μΩ-cm, 20°C

resistivity

5.0 μΩ-cm, 20°C

resistivity

5.0 μΩ-cm, 20°C

mp

2617 °C (lit.)

mp

2617 °C (lit.)

mp

2617 °C (lit.)

mp

2617 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

General description

HistoChoice® is a patented, complex mixture of agents that allow tissues to retain their structure, antigenic sites, and nucleic acid sites. It is a non-toxic, non-cross-linking fixative formulated to replace formaldehyde-based fixation. This formulation in non-citrus, contains no mercury, formaldehyde, or glutaraldehyde.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.

Application

HistoChoice® Clearing Agent has the following applications:
  • It is suitable as an alternative to toluene and xylene for dewaxing paraffin tissue sections. Prepared slides are suitable for antibody probing applications and in situ hybridizations.
  • It has been employed in a study to explain the recalcitrance of lignocellulosic plant cell walls to enzymatic degradation.[1]
  • It has been used to develop a novel method to improve sensitivity for the localization of miRNA and their target transcripts in plants.[2]
  • It has been used to study the correlation of cytoplasmic ADP-ribosylation levels with markers of patient outcome in human cancers.[3]

Biochem/physiol Actions

Fixation with HistoChoice® works well in immunohistology applications where its non-cross-linking traits are conducive to epitope retrieval and identification by primary antibodies to extracellular matrix components.

Features and Benefits

  • Non-toxic, non-carcinogenic, and odorless.
  • Non-flammable.
  • Preserves native antigenic and nucleic acid sites.
  • Compatible with many organic mounting media.
  • Dissolves wax faster and evaporates slower than xylene.
  • Can be used in automated processors.
  • Tissues retain their original structure.

Legal Information

HistoChoice is a registered trademark of Amresco, Inc.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

142.0 °F

Flash Point(C)

61.1 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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    Ralf R Mendel et al.
    Biochimica et biophysica acta, 1823(9), 1568-1579 (2012-03-01)
    The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity. With the exception of bacterial Mo-nitrogenase, where Mo is a constituent of the FeMo-cofactor, Mo is bound to a pterin, thus
    Tingyu Shi et al.
    Journal of cellular biochemistry, 112(10), 2721-2728 (2011-06-17)
    When intracelluar pathogens enter the host macrophages where in addition to oxidative and antibiotic mechanisms of antimicrobial activity, nutrients are deprived. Human pathogen Mycobacterium tuberculosis is one of macrophage parasitisms, which can replicate and persist for decades in dormancy state
    Bernd Masepohl et al.
    Advances in experimental medicine and biology, 675, 49-70 (2010-06-10)
    The vast majority of the purple nonsulfur photosynthetic bacteria are diazotrophs, but the details of the complex regulation of the nitrogen fixation process are well understood only for a few species. Here we review what is known of the well-studied
    Lidia Regoli et al.
    The Science of the total environment, 435-436, 96-106 (2012-08-01)
    In a regulatory context, bioaccumulation or bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. In this paper, literature data on the bioaccumulation of molybdenum in the aquatic organisms are
    Guenter Schwarz et al.
    Metal ions in life sciences, 13, 415-450 (2014-01-29)
    Molybdenum is an essential trace element and crucial for the survival of animals. Four mammalian Mo-dependent enzymes are known, all of them harboring a pterin-based molybdenum cofactor (Moco) in their active site. In these enzymes, molybdenum catalyzes oxygen transfer reactions

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