H3021
Antiflammin-2
≥97% (HPLC)
Synonym(s):
Anti-inflammatory peptide 2, His-Asp-Met-Asn-Lys-Val-Leu-Asp-Leu
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About This Item
Empirical Formula (Hill Notation):
C46H77N13O15S
CAS Number:
Molecular Weight:
1084.25
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CSCCC(NC(=O)C(CC(O)=O)NC(=O)C(N)Cc1cnc[nH]1)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(O)=O
assay
≥97% (HPLC)
composition
Peptide content, ~65%
storage temp.
−20°C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J M Ye et al.
Pharmaceutical research, 13(2), 250-255 (1996-02-01)
To study the oxidation of the methionine residue of antiflammin 2 (HDMNKVLDL, AF2) as a function of pH, buffer concentration, ionic strength, and temperature using different concentrations of hydrogen peroxide and to determine the accessibility of methionine residue to oxidation.
J J Moreno
European journal of pharmacology, 314(1-2), 129-135 (1996-10-24)
We have studied the effects of antiflammin-2, a fragment corresponding to amino acids 246-254 of lipocortin-1 (HDMNKVLDL), on arachidonate mobilization and metabolism and we also determined the effect of antiflammin-2 on the chemotaxis of phagocytes. Our results demonstrated that the
S Lloret et al.
Biochemical pharmacology, 50(3), 347-353 (1995-07-31)
Antiflammins are synthetic peptides with sequence homology to proteins inhibitory for phospholipase A2 (EC 3.1.1.4). The effect of antiflammin 2 on murine arachidonate or 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema has been studied. Topical application of arachidonic acid (AA) produced a
L Miele et al.
Nature, 335(6192), 726-730 (1988-10-20)
Significant future developments in the effective treatment of inflammatory diseases may arise from non-toxic dual inhibitors of both cyclooxygenase and lipoxygenase pathways in the arachidonate cascade. Inhibition of phospholipase A2(PLA2)(EC3.1.1.4), may provide such a dual action and recent research has
Wayne B Anderson et al.
Chemical research in toxicology, 17(5), 650-662 (2004-05-18)
Dichloroacetic acid (DCA) is a drinking water contaminant, a therapeutic agent, and a rodent carcinogen. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of alpha-haloalkanoates and the cis-trans isomerization of maleylacetoacetate. GSTZ1-1 catalyzes the bioactivation of fluorine-lacking dihaloacetates
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