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Merck
CN

H3131

2-Hydroxyestradiol

≥95% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-2,3-17β-triol, Estra-1,3,5(10)-triene-2,3,17-triol, NSC 61711

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About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
362-05-0
Molecular Weight:
288.38
NACRES:
NA.77
PubChem Substance ID:
24895552
UNSPSC Code:
12352200
MDL number:
MFCD00010490

Key Documents

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InChI

1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)c(O)cc34)[C@@H]1CC[C@@H]2O

InChI key

DILDHNKDVHLEQB-XSSYPUMDSA-N

biological source

synthetic (organic)

sterility

non-sterile

assay

≥95% (HPLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, faintly yellow to yellow

shipped in

ambient

storage temp.

−20°C

Gene Information

rat ... Ar(24208)

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH3649
MKCF9889
MKCC5942
MKBZ4229V
MKBX3313V

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R K Babbs et al.
Physiology & behavior, 103(5), 508-512 (2011-04-19)
One conundrum of binge eating is that women are more likely to suffer from binge-related disorders, even though estradiol decreases food intake. 2-hydroxyestradiol (2OHE2), an estrogen metabolite, may account for the contradiction, due to possible interference with DA signaling. We
Weidong Geng et al.
Journal of cellular physiology, 220(2), 332-340 (2009-04-11)
High [HCO(3)(-)] inhibits and low [HCO(3)(-)] stimulates bone resorption, which mediates part of the effect of chronic acidosis or acid feeding on bone. Soluble adenylyl cyclase (sAC) is a bicarbonate sensor that can potentially mediate the effect of bicarbonate on
G Basini et al.
The Journal of endocrinology, 199(1), 127-135 (2008-07-30)
The rapid, controlled, and cyclical nature of angiogenesis in the ovarian follicle suggests the potential for sex steroids to influence neovascularization. Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors. Multiple lines of evidence
Xiaoying Qiao et al.
Gender medicine, 5 Suppl A, S46-S64 (2008-05-28)
Sex hormones play a significant role in human physiology. Estrogen may have protective effects in the cardiovascular system, as evidenced by the decreased incidence of cardiovascular disease (CVD) in premenopausal compared with postmenopausal women. This review highlights the acute and
Christine Schlicker et al.
Journal of medicinal chemistry, 51(15), 4456-4464 (2008-07-18)
In mammals, the second messenger cAMP is synthesized by a family of transmembrane isoforms (tmACs) and one known cytoplasmic enzyme, "soluble" adenylyl cyclase (sAC). Understanding the individual contributions of these families to cAMP signaling requires tools which can distinguish them.
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