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Merck
CN

H3635

γ-Hydroxybutyric acid sodium salt

Synonym(s):

4-Hydroxybutyric acid sodium salt, γ-Hydroxybutyric acid sodium salt, GHB, Sodium 4-hydroxybutyrate

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About This Item

Linear Formula:
HO(CH2)3COONa
CAS Number:
502-85-2
Molecular Weight:
126.09
PubChem Substance ID:
24895583
UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
207-953-3
MDL number:
MFCD00004402
Beilstein/REAXYS Number:
3709170

Key Documents

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SMILES string

[Na+].OCCCC([O-])=O

drug control

USDEA Schedule I; Home Office Schedule 4.1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

Biochem/physiol Actions

Endogenous GABA analog that induces absence-like seizures. It blocks dopamine release by blocking impulse flow in dopaminergic neurons.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
127K5013
127F5093
127F5075
106H5018
089H3413

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G Tunnicliff
General pharmacology, 23(6), 1027-1034 (1992-11-01)
1. Administration of the endogenous compound gamma-hydroxybutyric acid (GHB) can induce a sleep-like state in experimental animals and, indeed, it has been used as a general anaesthetic in clinical medicine. 2. Although GHB appears to be a CNS depressant, there
M Hernandez et al.
The American journal of drug and alcohol abuse, 24(1), 179-183 (1998-03-26)
We describe what we believe is the first psychiatric hospitalization due to GHB-induced delirium reported in the medical literature. We examine the use of the substance gamma hydroxybutyric acid (GHB) and describe the clinical findings in a patient who presented
Wan-Ding Ong et al.
Journal of food science, 80(1), E93-E100 (2014-12-23)
Oil-in-water (O/W) emulsion-gel systems containing high oil payloads are of increasing interest for food applications because of the reduction in encapsulation cost, consumption frequency or volume of food products. This study shows a facile approach to prepare stable alginate-based O/W
Jae Seong Lee et al.
Journal of biotechnology, 161(1), 34-41 (2012-06-26)
Previous research showed that co-down-regulation of caspase-3/7 in rCHO cells, unlike Bcl-2 overexpression, did not effectively block apoptotic cell death induced by 3mM sodium butyrate (NaBu). Here, it is found that the control of autophagy is also related to this
Mashael K Alshaikh et al.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 8(4), 451-458 (2012-08-16)
To assess the efficacy and safety of sodium oxybate (SXB) in narcolepsy-cataplexy patients. Systematic review and meta-analysis. Adults with narcolepsy-cataplexy. SXB. Electronic databases (e.g., MEDLINE) and references of included studies were searched to identify randomized controlled trials (RCTs) assessing the
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