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Merck
CN

H3786

3′-p-Hydroxypaclitaxel

95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C47H51NO15
CAS Number:
132160-32-8
Molecular Weight:
869.91
UNSPSC Code:
12161501
MDL number:
MFCD03457859

Key Documents

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Product Name

3′-p-Hydroxypaclitaxel, 95% (HPLC), solid

form

solid

InChI

1S/C47H51NO15/c1-24-31(61-43(57)36(53)35(27-17-19-30(51)20-18-27)48-41(55)28-13-9-7-10-14-28)22-47(58)40(62-42(56)29-15-11-8-12-16-29)38-45(6,32(52)21-33-46(38,23-59-33)63-26(3)50)39(54)37(60-25(2)49)34(24)44(47,4)5/h7-20,31-33,35-38,40,51-53,58H,21-23H2,1-6H3,(H,48,55)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key

XKSMHFPSILYEIA-MZXODVADSA-N

assay

95% (HPLC)

storage temp.

−20°C

Quality Level

100

Application

Used for determining CYP3A4 activity.

Physical form

Each vial contains 20 nmoles (± 1%) (approx. 17.4 μg).

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCC0730
MKBW1198V
MKBV4527V
MKBR9385V
MKBS0473V

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Heleen A Bardelmeijer et al.
Anti-cancer drugs, 14(3), 203-209 (2003-03-14)
Previous mass balance studies in humans and mice have shown that the fecal and urinary recovery of paclitaxel and known metabolites (3' -hydroxypaclitaxel, 6alpha-hydroxypaclitaxel and 3',6alpha-dihydroxypaclitaxel) was not complete. Obviously this discrepancy is caused by the existence of other yet
Henrik Gréen et al.
Rapid communications in mass spectrometry : RCM, 20(14), 2183-2189 (2006-06-23)
A quantitative liquid chromatography/ion trap mass spectrometry method for the simultaneous determination of paclitaxel, 6alpha-hydroxypaclitaxel and p-3'-hydroxypaclitaxel in human plasma has been developed and validated. 6alpha-,p-3'-Dihydroxypaclitaxel was also quantified using paclitaxel as a reference and docetaxel as an internal standard.
M T Huizing et al.
Journal of chromatography. B, Biomedical applications, 674(2), 261-268 (1995-12-15)
A reversed-phase high-performance liquid chromatographic (HPLC) method has been validated for the quantitative determination of the three major paclitaxel metabolites (6 alpha-hydroxypaclitaxel, 3'-p-hydroxypaclitaxel, 6 alpha,3'-p-dihydroxypaclitaxel) in human plasma. The HPLC system consists of an APEX-octyl analytical column and acetonitrile-methanol-0.02 M
Wei Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(22), 2018-2022 (2011-06-28)
A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the determination of paclitaxel (Taxol) and its two major metabolites in human plasma has been developed. Samples were prepared after liquid-liquid extraction and analyzed on a C(18) column interfaced
Ryoko Taniguchi et al.
Journal of pharmacological sciences, 97(1), 83-90 (2005-01-19)
Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown that genetic
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