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H3878

Hyodeoxycholic acid

Name: Hyodeoxycholic acid
Brand: SIGMA

≥98%, Bile acid

Synonym(s):

3α,6α-Dihydroxy-5β-cholan-24-oic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₄₀O₄

CAS Number:

83-49-8

Molecular Weight:

392.57

NACRES:

NA.77

PubChem Substance ID:

24895601

UNSPSC Code:

12352106

EC Number:

201-483-2

MDL number:

MFCD00003681

Assay:

≥98%

Quality level:

200

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Product Name

Hyodeoxycholic acid, ≥98%

Quality Level

200

assay

≥98%

mp

200-201 °C (lit.)

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1

InChI key

DGABKXLVXPYZII-SIBKNCMHSA-N

Gene Information

human ... NR1H2(7376), NR1H3(10062)

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Bioactive Small Molecules

General description

Hyodeoxycholic acid is a naturally occurring secondary bile acid. It is produced by the gut flora in the small intestine. Hyodeoxycholic acid is obtained from chenodeoxycholic acid during enterohepatic circulation of bile in rats.

Application

Hyodeoxycholic acid has been used:

as a standard for serum bile acid profiling by liquid chromatography-mass spectrometry (LC-MS) method in rat cells.
as a component of the growth medium to study its effect as an anti-aging small molecule on the chronological life span (CLS) of the pex5Δ (Δ) strain.
as a standard for analyzing bile acid composition and total bile acids in mice cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000498366

0000487723

0000451005

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Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

Pierre J F, et al.

American Journal of Physiology: Gastrointestinal and Liver Physiology, 311(2), G286-G304 (2016)

Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition

Cepa S, et al.

Toxicology and Applied Pharmacology, 338(9), 204-213 (2018)

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.

Joseph F Pierre et al.

American journal of physiology. Gastrointestinal and liver physiology, 311(2), G286-G304 (2016-06-25)

The metabolic benefits induced by gastric bypass, currently the most effective treatment for morbid obesity, are associated with bile acid (BA) delivery to the distal intestine. However, mechanistic insights into BA signaling in the mediation of metabolic benefits remain an

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Goldberg A A, et al.

Aging (Albany. NY.), 2(7), 393-393 (2010)

On the Formation of Hyodeoxycholic Acid in the Rat BILE ACIDS AND STEROIDS 154

Einarsson K

The Journal of Biological Chemistry, 241(3), 534-539 (1966)

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Global Trade Item Number

SKU	GTIN
H3878-5G	04061832856612

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