H4524
Histone from calf thymus
suitable for substrate for protein kinase C
suitability
suitable for substrate for protein kinase C
storage temp.
2-8°C
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Application
Commonly used for chromosome-reconstitution studies.
Phosphorylation of this histone may also be suitable in other protein kinase systems.
Biochem/physiol Actions
Suitable substrate for protein kinase C.
Features and Benefits
Do not confuse Sigma "Type" designations with the "Fraction" designations used by Luck and co-workers.
Preparation Note
Isolated as a lysine-rich fraction.
Other Notes
Characterized as mainly subgroup f1 by SDS-PAGE
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Myung Hee Nam et al.
Proteome science, 10, 25-25 (2012-04-03)
The rice roots are highly salt-sensitive organ and primary root growth is rapidly suppressed by salt stress. Sucrose nonfermenting 1-related protein kinase2 (SnRK2) family is one of the key regulator of hyper-osmotic stress signalling in various plant cells. To understand
M P Suthar et al.
Indian journal of pharmaceutical sciences, 72(3), 290-294 (2010-12-29)
Cyclin-dependent kinases are most extensively studied targets for cancer chemotherapy since the tumor cells exhibit false checkpoints and can proliferate even if the genome is compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation
Ya-Lan Chang et al.
Nature communications, 8(1), 56-56 (2017-07-06)
Upon environmental changes, proliferating cells delay cell cycle to prevent further damage accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function and regulation of Cip1 are still poorly understood. Here we report that Cip1 expression is co-regulated
R D Cole
International journal of peptide and protein research, 30(4), 433-449 (1987-10-01)
The extent of microheterogeneity of H1 histones in individual higher organisms, without considering post-translational modifications, is such that five to eight molecular species can be recognized. The H1 variants differ among themselves in their ability to condense DNA and chromatin
Isolation of a homogeneous lysine-rich histone from calf thymus.
E de NOOIJ et al.
Biochimica et biophysica acta, 62, 608-609 (1962-08-27)
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