Key Documents

View All Documentation

H5257

Hispidin

Name: Hispidin
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), protein kinase Cβ, solid

Synonym(s):

6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₀O₅

CAS Number:

555-55-5

Molecular Weight:

246.22

UNSPSC Code:

12352200

PubChem Substance ID:

24278468

NACRES:

NA.77

MDL number:

MFCD01866972

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Hispidin, solid, ≥98% (HPLC)

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow to brown

mp

237.5-238.5 °C

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

InChI key

SGJNQVTUYXCBKH-HNQUOIGGSA-N

Gene Information

human ... PRKACB(5567), PRKAR2B(5577), PRKCB(5579)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Biochem/physiol Actions

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.

Potent inhibitor of protein kinase C_β, cytotoxic for cancer cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha.

Sirosh M Bokhari et al.

The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)

Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.

Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.

Prabodh Risal et al.

Journal of natural products, 75(10), 1683-1689 (2012-10-03)

In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection

KV1.5-KVβ1.3 Recycling Is PKC-Dependent.

Alvaro Macias et al.

International journal of molecular sciences, 22(3) (2021-02-13)

KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their

PKCbetaII modulates translation independently from mTOR and through RACK1.

Stefano Grosso et al.

The Biochemical journal, 415(1), 77-85 (2008-06-19)

RACK1 (receptor for activated C kinase 1) is an abundant scaffolding protein, which binds active PKCbetaII (protein kinase C betaII) increasing its activity in vitro. RACK1 has also been described as a component of the small ribosomal subunit, in proximity

Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line.

Isa M Hussaini et al.

The American journal of pathology, 170(1), 356-365 (2007-01-04)

The complete resection of pituitary adenomas (PAs) is unlikely when there is an extensive local dural invasion and given that the molecular mechanisms remain primarily unknown. DNA microarray analysis was performed to identify differentially expressed genes between nonfunctioning invasive and

View All Related Papers

Global Trade Item Number

SKU	GTIN
H5257-5MG	04061833798027

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service