H5653
8-Hydroxy-2′-deoxyguanosine
≥98% (TLC), DNA damage biomaker
Synonym(s):
8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O5
CAS Number:
Molecular Weight:
283.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Product Name
8-Hydroxy-2′-deoxyguanosine, ≥98% (TLC)
Quality Segment
assay
≥98% (TLC)
storage temp.
2-8°C
SMILES string
O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
InChI
1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
InChI key
HCAJQHYUCKICQH-UHFFFAOYSA-N
Application
8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo
- as a standard for LC/MS/MS analysis
Biochem/physiol Actions
The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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